INT1650

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Context Info
Confidence 0.28
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)
Anatomy Link Frequency
thyroid 1
follicle 1
fibroblast 1
TSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 16 100.00 Very High Very High Very High
Clonidine 12 100.00 Very High Very High Very High
Inflammation 13 98.60 Very High Very High Very High
opiate 2 72.72 Quite High
Pain 1 52.08 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular & Orbital Inflammation 3 98.92 Very High Very High Very High
Muscle Disease 12 91.28 High High
Autoimmune Disease 22 89.48 High High
INFLAMMATION 9 87.76 High High
Disorders Of The Lacrimal System 1 72.96 Quite High
Exophthalmos 2 66.12 Quite High
Thyroiditis 33 62.44 Quite High
Graves' Ophthalmopathy 31 57.20 Quite High
Hypothyroidism 1 53.04 Quite High
Diplopia 2 51.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of 2-Br-alpha-ergocryptine (2.5 mg/osM), clonidine (50 microgram, intramuscularly) and naloxone (0.4 mg, intramuscularly) as well as the interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PL) and thyroid-stimulating hormone (TSH) serum levels in normal man have been studied. 2-Br-alpha-ergocryptine and clonidine clearly reduce and naloxone tends to reduce PL serum levels.
Regulation (effects) of thyroid-stimulating hormone in follicle associated with narcan and clonidine
1) Confidence 0.28 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.91
A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone levels in normal man serum.
Regulation (effects) of thyroid-stimulating hormone in thyroid associated with narcan and clonidine
2) Confidence 0.28 Published 1979 Journal Neurosci. Lett. Section Title Doc Link 223091 Disease Relevance 0 Pain Relevance 0.94
A popular theory is that the primary reaction may involve antibodies targeting the TSH-r in the OCT which leads to orbital inflammation, manifest as orbital fibroblast stimulation, collagen and glycosaminoglycans (GAGS) production and associated congestive eye features.12 According to this theory, ocular myopathy is due to secondary, ischemic, damage to the eye muscles following primary OCT inflammation.
Regulation (targeting) of TSH-r in fibroblast associated with inflammation, muscle disease and ocular & orbital inflammation
3) Confidence 0.25 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.88 Pain Relevance 0.15

General Comments

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