INT165010

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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 6.65
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Hrh4) plasma membrane (Hrh4) signal transducer activity (Hrh4)
Anatomy Link Frequency
eosinophils 2
mast cells 2
neurons 1
DRG 1
T cells 1
Hrh4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 242 100.00 Very High Very High Very High
agonist 39 100.00 Very High Very High Very High
dorsal root ganglion 12 99.56 Very High Very High Very High
Peripheral nervous system 5 98.76 Very High Very High Very High
chemokine 30 97.90 Very High Very High Very High
Inflammation 308 96.32 Very High Very High Very High
cytokine 250 93.48 High High
Antihistamine 6 86.36 High High
Kinase C 6 85.68 High High
qutenza 2 82.76 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 99.56 Very High Very High Very High
Asthma 263 97.44 Very High Very High Very High
INFLAMMATION 329 96.32 Very High Very High Very High
Hyperplasia 78 85.04 High High
Targeted Disruption 11 83.60 Quite High
Hypersensitivity 71 79.60 Quite High
Pneumonia 24 78.88 Quite High
Pain 6 74.28 Quite High
Hyperalgesia 2 69.76 Quite High
Fibrosis 6 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H4R is functionally expressed on many cell types intimately associated with the pathology of asthma, such as eosinophils, basophils, mast cells, dendritic cells and CD8+ T cells, as recently reviewed [7].
Gene_expression (expressed) of H4R in T cells associated with asthma
1) Confidence 0.73 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.84 Pain Relevance 0.29
From a range of chemokines measured, corrected for total protein levels, only CCL3, CCL5 and CCL11 were modulated significantly by H4R antagonism or ani-IL-13 treatment.
Gene_expression (antagonism) of H4R associated with chemokine
2) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.11 Pain Relevance 0.29
All of these parameters were blocked both by H4R antagonism and anti-IL-13 treatment.
Gene_expression (antagonism) of H4R
3) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.77 Pain Relevance 0.16
A comparable study, in which H4R antagonist, but not anti-IL-13 was examined revealed an additional dose dependent and significant inhibition of CCL17 (TARC) production via H4R antagonism (see figure S2, additional file 2).


Spec (examined) Gene_expression (examined) of H4R associated with antagonist
4) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.22 Pain Relevance 0.32
This may result from the continued activation of memory T cells in the more chronic setting, and its progressive attenuation under H4R blockade.
Gene_expression (blockade) of H4R in memory T cells
5) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.14 Pain Relevance 0.29
The potentiating effect of histamine was mimicked by an H1R agonist, but not H2R-H4R agonists and was inhibited only by an H1R antagonist.
Gene_expression (agonist) of H2R-H4R associated with antagonist and agonist
6) Confidence 0.59 Published 2010 Journal Neuroscience Section Abstract Doc Link 20006972 Disease Relevance 1.00 Pain Relevance 0.94
Treatment with both H4R, 20 mg/kg, and anti-IL-13 reduced free collagen levels (vehicle, 55.83 ± 2.4 ?
Gene_expression (Treatment) of H4R
7) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.87 Pain Relevance 0.17
RT-PCR indicated the expression of all four histamine receptors (H1R, H2R, H3R, H4R) in mouse DRG.
Gene_expression (expression) of H4R in DRG associated with dorsal root ganglion
8) Confidence 0.53 Published 2010 Journal Neuroscience Section Abstract Doc Link 20006972 Disease Relevance 1.02 Pain Relevance 0.91
Unlike the other histamine receptors, H4 receptor (H4R) is predominantly expressed on hematopoietic cells [10], [11], [12], and H4R agonists were shown to induce chemotaxis of mast cells and eosinophils [13] as well as the production of IL-16 by T cells [14].
Gene_expression (expressed) of H4R in eosinophils associated with agonist
9) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.35 Pain Relevance 0.39
In contrast to H1R, H2R, and H4R, H3R are mainly expressed in neurons of the central and peripheral nervous system [16].
Gene_expression (expressed) of H4R in neurons associated with peripheral nervous system
10) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.26 Pain Relevance 0.41
Unlike the other histamine receptors, H4 receptor (H4R) is predominantly expressed on hematopoietic cells [10], [11], [12], and H4R agonists were shown to induce chemotaxis of mast cells and eosinophils [13] as well as the production of IL-16 by T cells [14].
Gene_expression (expressed) of H4 receptor in eosinophils associated with agonist
11) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.35 Pain Relevance 0.39
Unlike the other histamine receptors, H4 receptor (H4R) is predominantly expressed on hematopoietic cells [10], [11], [12], and H4R agonists were shown to induce chemotaxis of mast cells and eosinophils [13] as well as the production of IL-16 by T cells [14].
Gene_expression (expressed) of H4 receptor in mast cells associated with agonist
12) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.35 Pain Relevance 0.39
Unlike the other histamine receptors, H4 receptor (H4R) is predominantly expressed on hematopoietic cells [10], [11], [12], and H4R agonists were shown to induce chemotaxis of mast cells and eosinophils [13] as well as the production of IL-16 by T cells [14].
Gene_expression (expressed) of H4R in mast cells associated with agonist
13) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.35 Pain Relevance 0.39

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