INT165014

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC12A5) plasma membrane (SLC12A5) transmembrane transport (SLC12A5)
Anatomy Link Frequency
dorsal horn 1
SLC12A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 99.56 Very High Very High Very High
gABA 3 97.48 Very High Very High Very High
Dorsal horn neuron 1 97.40 Very High Very High Very High
Peripheral nerve injury 2 92.08 High High
Neuropathic pain 4 88.08 High High
Versed 3 75.00 Quite High
GABAergic 1 68.08 Quite High
allodynia 2 32.96 Quite Low
neuralgia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 2 92.08 High High
Neuropathic Pain 9 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down-regulation of KCC2 is expected to cause a reduction in Cl(-) extrusion capacity in dorsal horn neurons, which, together with the depolarizing efflux of HCO(3)(-) anions via GABA(A) channels, would result in a decrease in the efficacy of GABA(A)-mediated inhibition.
Regulation (regulation) of KCC2 in dorsal horn associated with gaba and dorsal horn neuron
1) Confidence 0.45 Published 2010 Journal Pain Section Abstract Doc Link 20007010 Disease Relevance 0.37 Pain Relevance 0.59

General Comments

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