INT165036

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 38
Total Number 42
Disease Relevance 38.33
Pain Relevance 7.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a9) extracellular region (S100a9) plasma membrane (S100a9)
cytoskeleton (S100a9) nucleus (S100a9) cytoplasm (S100a9)
Anatomy Link Frequency
neutrophils 7
macrophages 3
keratinocytes 3
bladder 2
kidney 2
S100a9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1314 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
rheumatoid arthritis 91 99.68 Very High Very High Very High
Central nervous system 121 98.92 Very High Very High Very High
cytokine 301 98.68 Very High Very High Very High
member 8 4 95.24 Very High Very High Very High
Neurotransmitter 2 93.20 High High
Multiple sclerosis 8 91.04 High High
dopamine receptor 1 84.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1526 100.00 Very High Very High Very High
Mycobacterial Infection 582 100.00 Very High Very High Very High
Urinary Tract Infection 294 99.98 Very High Very High Very High
Targeted Disruption 381 99.96 Very High Very High Very High
Conjunctiva Disease 13 99.84 Very High Very High Very High
Chemotherapy-induced Neutropenia 13 99.76 Very High Very High Very High
Rheumatoid Arthritis 92 99.68 Very High Very High Very High
Disease 306 99.42 Very High Very High Very High
Chemical Burns 78 99.36 Very High Very High Very High
Schistosomiasis 37 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of neutrophils abrogated S-CorNV and S100A8 and S100A9 production
Gene_expression (production) of S100A9 in neutrophils
1) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.46 Pain Relevance 0.07
Considering the above observation that S100A8 and S100A9 proteins are located in both neutrophils and macrophages (Figure 2), we suggest that S100A8 (and S100A9) produced by neutrophils attracted more neutrophils in turn, thus forming a positive feedback in certain stages of inflammatory CorNV.
Gene_expression (produced) of S100A9 in neutrophils associated with inflammation
2) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.41 Pain Relevance 0.18
We further showed that depletion of neutrophils decreased S100A8 and S100A9 expression in S-CorNV corneas compared to control S-CorNV corneas (Figure 3).
Gene_expression (expression) of S100A9 in corneas associated with chemotherapy-induced neutropenia
3) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.49 Pain Relevance 0.11
Recently, S100A6, S100A8, and S100A9 were found to be extensively expressed in pterygium tissue removed from patients [41,42].
Gene_expression (expressed) of S100A9 associated with conjunctiva disease
4) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.84 Pain Relevance 0.16
It should also be noted that not all neutrophils or macrophages stained positive for S100A8 or S100A9, demonstrating the heterogeneity of the infiltrated neutrophils or macrophages.
Neg (not) Gene_expression (stained) of S100A9 in macrophages
5) Confidence 0.66 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.36 Pain Relevance 0.07
Immunohistochemistry analysis of the S-CorNV corneas showed that S100A8 and S100A9 were deposited in the neovascularized corneas (Figure 2).
Gene_expression (deposited) of S100A9 in corneas
6) Confidence 0.66 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.27 Pain Relevance 0.07
In summary, the above data shows that the changes of expression of the S100A8 and S100A9 genes, as well as several other cytokines, changed in concert with the growth and atrophy of new vessels in the S-CorNV model.
Gene_expression (expression) of S100A9 in vessels associated with frailty and cytokine
7) Confidence 0.66 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.39 Pain Relevance 0.20
To conclude, we found that S100A8 and S100A9 were involved in the inflammatory CorNV model.
Gene_expression (involved) of S100A9 associated with inflammation
8) Confidence 0.66 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.59 Pain Relevance 0.17
Thus comparative studies of mice that are deficient in S100A8 or S100A9 (e.g., gene knockout mice of such genes) will help to determine how these two genes take their effects in the development of CorNV under various conditions.
Gene_expression (deficient) of S100A9 associated with targeted disruption
9) Confidence 0.66 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.38 Pain Relevance 0.11
Evidence for linkage was, however, detected when markers on chromosome 10p12-p14 situated close to the ARVD6 locus were investigated.
Gene_expression (situated) of p14
10) Confidence 0.65 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1444927 Disease Relevance 0.90 Pain Relevance 0.08
The heterophilic binding partner of MRP8 is MRP14, which does not appear in the same cluster but rather is expressed within the early inflammation cluster (see later), since, in addition to keratinocyte expression, it is expressed at high levels by wound leukocytes.
Gene_expression (expressed) of MRP14 in leukocytes associated with inflammation and injury
11) Confidence 0.62 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.50 Pain Relevance 0.08
In situ hybridization clearly shows MRP14 to be expressed, in addition to expression in keratinocytes, in the region of the wound populated by inflammatory cells in the wild-type only (Figure 7Ak,l), and indeed, previous experiments suggest that both neutrophils and macrophages express MRP8 and MRP14 [22].
Gene_expression (express) of MRP14 in keratinocytes associated with inflammation and injury
12) Confidence 0.62 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.18 Pain Relevance 0.26
In situ hybridization clearly shows MRP14 to be expressed, in addition to expression in keratinocytes, in the region of the wound populated by inflammatory cells in the wild-type only (Figure 7Ak,l), and indeed, previous experiments suggest that both neutrophils and macrophages express MRP8 and MRP14 [22].
Gene_expression (expressed) of MRP14 in keratinocytes associated with inflammation and injury
13) Confidence 0.62 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.13 Pain Relevance 0.26
Immunofluorescence analysis demonstrated that neutrophils and macrophages produce S100A8 and S100A9.
Gene_expression (produce) of S100A9 in neutrophils
14) Confidence 0.59 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994359 Disease Relevance 0.50 Pain Relevance 0.24
Among these, S100A9 was present in exudates within 4 h of initiating inflammation and reached maximum levels at the onset of Ri (12 h).
Gene_expression (present) of S100A9 associated with inflammation
15) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.68 Pain Relevance 0.54
As a control, S100A9 staining was absent in renal tissue slides obtained from S100A9 KO mice subjected to UTI (data not shown).


Neg (absent) Gene_expression (staining) of S100A9 associated with targeted disruption and urinary tract infection
16) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.78 Pain Relevance 0.04
The heterophilic binding partner of MRP8 is MRP14, which does not appear in the same cluster but rather is expressed within the early inflammation cluster (see later), since, in addition to keratinocyte expression, it is expressed at high levels by wound leukocytes.
Gene_expression (expressed) of MRP14 in leukocytes associated with inflammation and injury
17) Confidence 0.54 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.50 Pain Relevance 0.08
This study is the first to investigate the expression, localization, and role of S100A9 in a local E. coli-induced infection of the urinary tract system.
Spec (investigate) Gene_expression (expression) of S100A9 associated with infection
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 2.18 Pain Relevance 0.19
Among these, S100A9 was present in exudates within 4 h of initiating inflammation and reached maximum levels at the onset of Ri (12 h).
Gene_expression (onset) of S100A9 associated with inflammation
19) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.70 Pain Relevance 0.56
This study is the first to describe the contribution of S100A8/A9 during (E.coli-induced) UTI using S100A9 KO mice.
Gene_expression (using) of S100A9 associated with targeted disruption and urinary tract infection
20) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.10 Pain Relevance 0.12

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