INT165047

Context Info Confidence 0.73 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.80 Pain Relevance 0.63

mitochondrion (Mapk14) cell morphogenesis (Mapk14) intracellular (Tnf) extracellular matrix organization (Tnf) response to stress (Mapk14) cytoplasm (Mapk14)

Mapk14 (Rattus norvegicus) Tnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 2 98.72 Neuropeptide 1 94.44 Calcitonin gene-related peptide 8 93.92 backache 1 91.76 dorsal root ganglion 6 86.64 Root ganglion neuron 1 75.00

Disease Link Frequency Relevance Heat Pain 2 98.72 Necrosis 1 95.28 Cancer 1 94.92 Low Back Pain 1 91.76 Ganglion Cysts 7 86.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because p38 mitogen-activated protein kinase (p38) upregulates TNF-alpha expression and may play a crucial role in pain sensation, we investigated the effect of one injection of inhibitor on expression of the pain-related neuropeptide calcitonin gene-related peptide (CGRP).

p38 Positive_regulation (upregulates) of Gene_expression (expression) of TNF-alpha associated with pain, neuropeptide and calcitonin gene-related peptide

1) Confidence 0.73 Published 2009 Journal Spine Section Abstract Doc Link 20010392 Disease Relevance 0.80 Pain Relevance 0.63

General Comments

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