INT165056

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.93
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (MID1) ligase activity (MID1) cytoplasm (MID1)
Anatomy Link Frequency
brain 2
MID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 3 100.00 Very High Very High Very High
Sumatriptan 7 98.64 Very High Very High Very High
Inflammation 15 92.44 High High
Triptan 1 82.52 Quite High
Neurotransmitter 4 40.48 Quite Low
Inflammatory stimuli 1 39.40 Quite Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 3 100.00 Very High Very High Very High
INFLAMMATION 20 92.44 High High
Sepsis 23 90.32 High High
Encephalopathy 14 84.28 Quite High
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been discussed whether a defect in the BBB during migraine attacks could be responsible for a possible central effect of sumatriptan in migraine.
Regulation (responsible) of Gene_expression (defect) of BBB associated with sumatriptan and migraine
1) Confidence 0.39 Published 2010 Journal J Headache Pain Section Abstract Doc Link 20012125 Disease Relevance 0.29 Pain Relevance 0.99
Thus, if it is assumed that the kinetic constants for phenylalanine transfer across the BBB are not affected by the LPS challenge, the present study provides direct evidence that links the alterations in the BCAA/AAA ratio with changes in the brain's amino acid content in the context of systemic inflammation.
Neg (not) Regulation (affected) of Gene_expression (transfer) of BBB in brain associated with inflammation
2) Confidence 0.07 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0.64 Pain Relevance 0.11

General Comments

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