INT165057

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.13
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (MID1) ligase activity (MID1) cytoplasm (MID1)
Anatomy Link Frequency
blood 1
MID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 11 99.84 Very High Very High Very High
Sumatriptan 14 99.60 Very High Very High Very High
Central nervous system 19 99.40 Very High Very High Very High
Inflammation 9 98.20 Very High Very High Very High
Migraine 6 97.62 Very High Very High Very High
Spinal cord 12 96.04 Very High Very High Very High
Triptan 2 92.00 High High
Demyelination 4 88.00 High High
Electroencephalography 13 77.56 Quite High
Multiple sclerosis 43 73.28 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 65 100.00 Very High Very High Very High
Pressure And Volume Under Development 8 99.70 Very High Very High Very High
INFLAMMATION 8 98.20 Very High Very High Very High
Headache 6 97.62 Very High Very High Very High
Injury 17 97.20 Very High Very High Very High
Frailty 1 96.80 Very High Very High Very High
Spinal Cord Cancer 2 96.32 Very High Very High Very High
Central Nervous System Disease 5 96.24 Very High Very High Very High
Gliosis 1 94.96 High High
Cancer 12 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In more recent animal studies there are strong indications that sumatriptan to some extent can cross the BBB.
BBB Binding (cross) of associated with sumatriptan
1) Confidence 0.32 Published 2010 Journal J Headache Pain Section Abstract Doc Link 20012125 Disease Relevance 0.25 Pain Relevance 0.93
The CNS adverse events of sumatriptan in migraine patients and normal volunteers also indicate a more general effect of sumatriptan on CNS indicating that the drug can cross the BBB in man.
BBB Binding (cross) of associated with sumatriptan and migraine
2) Confidence 0.32 Published 2010 Journal J Headache Pain Section Abstract Doc Link 20012125 Disease Relevance 0.28 Pain Relevance 0.98
According to OS, which is based on introspection and linguistic data, the meanings of words can be analyzed in terms of elemental mental operations (EOMC), amongst which those of attention play a key role.
OS Binding (introspection) of
3) Confidence 0.04 Published 2010 Journal The Open Neuroimaging Journal Section Abstract Doc Link PMC2948146 Disease Relevance 0.05 Pain Relevance 0
Bradykinin (BK), an inflammatory mediator in the kinin-kallikrein system, may contribute to cerebral oedema by increasing permeability of the BBB.
BBB Binding (permeability) of associated with pressure and volume under development, inflammation and bradykinin
4) Confidence 0.02 Published 2009 Journal Trials Section Body Doc Link PMC2794266 Disease Relevance 1.03 Pain Relevance 0.40
Cell trafficking at the BBB
BBB Binding (trafficking) of
5) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2842276 Disease Relevance 0.28 Pain Relevance 0.23
These findings suggest that a humoral effector mechanism is initiated by binding of the NMO antibody at the blood-brain barrier (BBB).
BBB Binding (binding) of in blood associated with neuromyelitis optica
6) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2904295 Disease Relevance 2.24 Pain Relevance 0.58
Also recognized is the sensibility of these values as charged substances do not easily cross the BBB.
BBB Binding (recognized) of
7) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754920 Disease Relevance 0 Pain Relevance 0

General Comments

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