INT165058

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 10.82
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (MID1) ligase activity (MID1) cytoplasm (MID1)
Anatomy Link Frequency
brain 5
neuronal 1
circulating cells 1
immune cells 1
tendon 1
MID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 6 99.68 Very High Very High Very High
bradykinin 15 99.52 Very High Very High Very High
Electroencephalography 26 98.96 Very High Very High Very High
cytokine 174 98.72 Very High Very High Very High
Central nervous system 89 97.98 Very High Very High Very High
Sumatriptan 14 97.48 Very High Very High Very High
imagery 139 97.16 Very High Very High Very High
anesthesia 24 96.04 Very High Very High Very High
Inflammatory mediators 10 95.04 Very High Very High Very High
Inflammation 91 93.76 High High
Disease Link Frequency Relevance Heat
Breast Cancer 168 99.80 Very High Very High Very High
Pressure And Volume Under Development 16 99.72 Very High Very High Very High
Headache 22 99.68 Very High Very High Very High
Brain Injury 40 99.58 Very High Very High Very High
Neurodegenerative Disease 16 99.58 Very High Very High Very High
Metastasis 304 99.24 Very High Very High Very High
Injury 33 99.22 Very High Very High Very High
Cancer 390 98.76 Very High Very High Very High
Sepsis 46 98.40 Very High Very High Very High
Central Nervous System Disease 5 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been discussed whether a defect in the BBB during migraine attacks could be responsible for a possible central effect of sumatriptan in migraine.
Negative_regulation (defect) of BBB associated with sumatriptan and migraine
1) Confidence 0.37 Published 2010 Journal J Headache Pain Section Abstract Doc Link 20012125 Disease Relevance 0.29 Pain Relevance 0.98
This review suggests that there is no need for a breakdown in the BBB to occur in order to explain a possible central CNS effect of sumatriptan.
Negative_regulation (breakdown) of BBB associated with sumatriptan
2) Confidence 0.37 Published 2010 Journal J Headache Pain Section Abstract Doc Link 20012125 Disease Relevance 0.28 Pain Relevance 0.96
Since two theories (OS and OA) and their possible correspondence have to be introduced in the restricted space of an article, only the essential outlines of OS are shown here.
Negative_regulation (introduced) of OS
3) Confidence 0.05 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0 Pain Relevance 0
BK is produced immediately after injury and appears to be a potent endogenous disruptor of the BBB [2].
Negative_regulation (disruptor) of BBB associated with injury and bradykinin
4) Confidence 0.03 Published 2009 Journal Trials Section Body Doc Link PMC2794266 Disease Relevance 1.12 Pain Relevance 0.47
When maximal BBB disruption was achieved, changes in EEG frequency were observed (Figure 7).
Negative_regulation (disruption) of BBB associated with electroencephalography
5) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2842276 Disease Relevance 0.10 Pain Relevance 0.31
Our data show that brain penetration of peripherally circulating cells requires BBB disruption and it is limited to the immediate perivascular space.
Negative_regulation (disruption) of BBB in circulating cells
6) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2842276 Disease Relevance 0.55 Pain Relevance 0
Astrocytes interact extensively with endothelial cells to maintain the CNS BBB, which normally limits the access of immune system effectors unless localized or distant events disrupt the BBB, thus allowing access of cellular or soluble immune effectors.
Negative_regulation (disrupt) of BBB in immune system associated with central nervous system
7) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2904295 Disease Relevance 1.58 Pain Relevance 0.49
The impairment of the BBB was observed recently in breast cancer patients who developed metastasis to the brain [5].
Negative_regulation (impairment) of BBB in brain associated with breast cancer and metastasis
8) Confidence 0.01 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.65 Pain Relevance 0.09
Impairment of the BBB leads to an increase in permeability and formation of edema.
Negative_regulation (Impairment) of BBB associated with pressure and volume under development
9) Confidence 0.01 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.62 Pain Relevance 0.21
Most forms of brain injury are associated with BBB disruption, resulting in secondary damage to neural cells.
Negative_regulation (disruption) of BBB in neural associated with brain injury
10) Confidence 0.01 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.44 Pain Relevance 0.19
Here, we have delineated the mechanisms of BBB impairment and breast cancer metastasis to the brain.
Negative_regulation (impairment) of BBB in brain associated with breast cancer and metastasis
11) Confidence 0.01 Published 2011 Journal Pathology Research International Section Abstract Doc Link PMC3021881 Disease Relevance 1.10 Pain Relevance 0
Of particular interest, US-mediated disruption of the BBB has been previously shown to significantly enhance drug delivery to the brain (18,19).
Negative_regulation (disruption) of BBB in brain
12) Confidence 0.01 Published 2010 Journal AAPS PharmSciTech Section Body Doc Link PMC2974134 Disease Relevance 0.33 Pain Relevance 0
It was shown that using low-energy focused US pulses combined with an US contrast agent could reversibly disrupt the BBB in the US-targeted regions of the brain without adverse effects in the brain tissue.
Negative_regulation (disrupt) of BBB in brain
13) Confidence 0.01 Published 2010 Journal AAPS PharmSciTech Section Body Doc Link PMC2974134 Disease Relevance 0 Pain Relevance 0
Considerable evidence indicates that when over produced, these cytokines mediate diverse range of neurodegenerative functions including disruption of the BBB, chemoattraction of peripheral immune cells and neuronal damage [35,41].
Negative_regulation (disruption) of BBB in neuronal associated with neurodegenerative disease and cytokine
14) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 1.39 Pain Relevance 0.42
However, brain vasogenic edema, caused by a breakdown in the BBB was not observed in the early phase of sepsis in endotoxic rats using magnetic resonance imaging (MRI), despite the presence of microcirculatory disturbances in those animals [53], suggesting that brain edema occurs later and may be a consequence, rather than a cause, of cerebral microcirculatory disturbances.
Negative_regulation (breakdown) of BBB in brain associated with pressure and volume under development, cerebral edema, imagery and sepsis
15) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2945121 Disease Relevance 0.70 Pain Relevance 0.10
Achilles tendon postcapillary venous filling pressures were significantly reduced at the insertion (51 ± 16 vs.41 ± 19, p = 0.001) and the distal mid-portion (36 ± 13 vs.32 ± 12, p = 0.037) at 2 mm and at the insertion at 8 mm (63 ± 19 vs.51 ± 13, p = 0.0001).
Negative_regulation (reduced) of mid-portion in tendon
16) Confidence 0.00 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.25 Pain Relevance 0.04
Considerable evidence indicates that when over produced, these cytokines mediate diverse range of neurodegenerative functions including disruption of the BBB, chemoattraction of peripheral immune cells and neuronal damage [35,41].
Negative_regulation (disruption) of BBB in immune cells associated with neurodegenerative disease and cytokine
17) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 1.39 Pain Relevance 0.42

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