INT165059

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 3.68
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (MID1) ligase activity (MID1) cytoplasm (MID1)
Anatomy Link Frequency
brain 2
leukocyte 1
endothelium 1
MID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 3 99.68 Very High Very High Very High
b2 receptor 7 97.52 Very High Very High Very High
Sumatriptan 7 96.84 Very High Very High Very High
bradykinin 11 96.76 Very High Very High Very High
Neurotransmitter 12 95.60 Very High Very High Very High
Inflammation 80 93.52 High High
Pain 7 92.96 High High
cytokine 28 91.04 High High
antagonist 16 83.60 Quite High
tolerance 6 83.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 40 99.84 Very High Very High Very High
Headache 3 99.68 Very High Very High Very High
Pressure And Volume Under Development 18 99.32 Very High Very High Very High
Injury 61 96.72 Very High Very High Very High
INFLAMMATION 110 93.52 High High
Pain 7 92.96 High High
Sepsis 71 90.96 High High
Toxicity 6 86.44 High High
Brain Injury 97 85.04 High High
Encephalopathy 42 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been discussed whether a defect in the BBB during migraine attacks could be responsible for a possible central effect of sumatriptan in migraine.
Gene_expression (defect) of BBB associated with sumatriptan and migraine
1) Confidence 0.58 Published 2010 Journal J Headache Pain Section Abstract Doc Link 20012125 Disease Relevance 0.29 Pain Relevance 0.98
Given that the BBB transport of a substance can be described accurately by means of a single-membrane model in which the cerebrovascular endothelium behaves as a single membrane, which is the case for LNAAs [23], the unidirectional cerebral influx of phenylalanine (Jin, Phe) can be calculated
Gene_expression (transport) of BBB in endothelium
2) Confidence 0.18 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0 Pain Relevance 0
An unchanged cerebral net exchange could furthermore involve changes in BBB function per se through a compensatory increase in the unidirectional cerebral efflux of phenylalanine, a parameter that was not assessed in the present study.
Gene_expression (function) of BBB
3) Confidence 0.18 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0.27 Pain Relevance 0.08
Thus, if it is assumed that the kinetic constants for phenylalanine transfer across the BBB are not affected by the LPS challenge, the present study provides direct evidence that links the alterations in the BCAA/AAA ratio with changes in the brain's amino acid content in the context of systemic inflammation.
Gene_expression (transfer) of BBB in brain associated with inflammation
4) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0.64 Pain Relevance 0.11
Another finding from this study was that the mid-ventricular section shows the maximum ?
Gene_expression (section) of mid-ventricular
5) Confidence 0.08 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2856559 Disease Relevance 0.15 Pain Relevance 0.03
The fundamental thesis of OS is that these words designate sequences of mental operations (the name “Operational Semantics” derives from this), amongst which the ones of attention play a key role.
Gene_expression (thesis) of OS
6) Confidence 0.07 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0.13 Pain Relevance 0
In fact, as we have seen in the second section, according to OS, both these correlations are produced by presence keeping.
Gene_expression (produced) of OS
7) Confidence 0.07 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0 Pain Relevance 0
As we have seen, OS hypothesises the existence of three operational levels in linguistic thought, which can be related to OMs of different complexity in the OA framework:
Gene_expression (hypothesises) of OS
8) Confidence 0.07 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0 Pain Relevance 0
We believe that the best way to introduce OS is exactly to consider language itself.
Gene_expression (introduce) of OS
9) Confidence 0.07 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0 Pain Relevance 0
After subcutaneous injection Anatibant is bio-available and crosses the BBB.
Gene_expression (crosses) of BBB
10) Confidence 0.04 Published 2009 Journal Trials Section Body Doc Link PMC2794266 Disease Relevance 0.96 Pain Relevance 0.73
Figure 4 shows an example of histological appearance of brain sections from an animal where BBB disruption was not induced; this was also previously quantified by contrast-enhanced MRI and post-mortem histological evaluation of Evan Blue (Figure 2).
Gene_expression (disruption) of BBB in brain
11) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2842276 Disease Relevance 0 Pain Relevance 0
An initial exposure of 2 days was sufficient to reduce OS gene expression, and an initial exposure of 4 days was sufficient to reduce AD gene expression.
Gene_expression (expression) of OS gene
12) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Ouabain treatment significantly suppressed both AD and OS gene expression, although the fold-changes are smaller than to those seen with high [K+]out treatment.
Gene_expression (expression) of OS gene
13) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0.12
induces capillary leak and edema formation [28], causing enhanced BBB permeability [29] and upregulated expression of adhesion molecules such as ICAM-1 and VCAM-1 on the surface of brain ECs and glial cells [24,85], exacerbating intracerebral leukocyte infiltration and microcirculatory dysfunction [23,41].
Gene_expression (expression) of BBB in leukocyte associated with pressure and volume under development and adhesions
14) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.24 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox