INT165066

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.82
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Cytotoxic T-lymphocyte 2
T cells 1
GAGE4 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 1 97.32 Very High Very High Very High
spinal inflammation 2 88.96 High High
tolerance 9 81.04 Quite High
Etanercept 6 79.84 Quite High
Adalimumab 2 76.08 Quite High
Infliximab 21 71.12 Quite High
cytokine 40 69.92 Quite High
antagonist 2 68.28 Quite High
corticosteroid 24 47.84 Quite Low
Inflammation 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 13 99.52 Very High Very High Very High
Solid Tumor 5 98.96 Very High Very High Very High
Cancer 172 96.16 Very High Very High Very High
Carcinoma 2 92.48 High High
Sarcoidosis 20 91.12 High High
Autoimmune Disease 24 88.08 High High
Apoptosis 40 86.08 High High
Pulmonary Disease 3 84.00 Quite High
Glioma 5 83.52 Quite High
Skin Cancer 5 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(NCT00955279); ustekinumab, a human anti-interleukin-12/interleukin-23 monoclonal antibody (NCT00955279); and abatacept, a fusion protein composed of the Fc fraction of human immunoglobulin G1 fused to the extracellular domain of cytotoxic T-lymphocyte antigen 4 (NCT00739960), an inhibitory molecule expressed on the surface of helper T cells.
Gene_expression (expressed) of antigen 4 in cytotoxic T-lymphocyte associated with abatacept
1) Confidence 0.09 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948401 Disease Relevance 0.60 Pain Relevance 0.36
Also, the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a regulator of the effector function of T cells, is expressed in various leukemias and solid tumors [304].
Gene_expression (expressed) of antigen-4 in T cells associated with leukemia and solid tumor
2) Confidence 0.01 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 2.15 Pain Relevance 0.04
INTRODUCTION: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a costimulatory molecule expressed by activated T cells.
Gene_expression (expressed) of antigen 4 in Cytotoxic T-lymphocyte
3) Confidence 0.00 Published 2010 Journal J. Clin. Immunol. Section Abstract Doc Link 20012554 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

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