INT165078

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CTSB, Notch1) cell differentiation (Notch1) mitochondrion (CTSB)
Golgi apparatus (Notch1) intracellular (CTSB) embryo development (Notch1)
Anatomy Link Frequency
Notch 1
CTSB (Homo sapiens)
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Abeta 6 100.00 Very High Very High Very High
cINOD 3 91.36 High High
Potency 1 56.32 Quite High
Disease Link Frequency Relevance Heat
Toxicity 2 99.58 Very High Very High Very High
Disease 7 93.12 High High
INFLAMMATION 1 89.92 High High
Amyloid Plaque 1 86.24 High High
Alzheimer's Dementia 2 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many inhibitors of this protease have been identified, although the clinical use has been limited by concerns about the possible toxicity of these compounds. gamma-secretase inhibitors have been shown to reduce Abeta in vitro and in vivo, but interference with Notch proteolysis causes immunological and gastrointestinal toxicity in animal models.
gamma-secretase Binding (interference) of Notch in Notch associated with toxicity and abeta
1) Confidence 0.00 Published 2010 Journal Curr Drug Targets Section Abstract Doc Link 20015011 Disease Relevance 1.08 Pain Relevance 0.48

General Comments

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