INT165081

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.79
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
Muscle 2
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 12 100.00 Very High Very High Very High
Inflammation 16 99.98 Very High Very High Very High
antagonist 6 99.16 Very High Very High Very High
Glutamate 23 98.24 Very High Very High Very High
Root ganglion neuron 2 96.48 Very High Very High Very High
Hyperalgesia 22 93.52 High High
medulla 5 74.12 Quite High
Hippocampus 9 59.84 Quite High
agonist 9 45.96 Quite Low
nociceptor 4 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.98 Very High Very High Very High
Targeted Disruption 10 99.64 Very High Very High Very High
Ganglion Cysts 2 96.16 Very High Very High Very High
Hyperalgesia 22 94.32 High High
Acidosis 2 90.88 High High
Injury 6 87.76 High High
Body Weight 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Neg (not) Positive_regulation (causes) of Neg (not) Positive_regulation (increases) of ASIC1a in Muscle associated with inflammation
1) Confidence 0.49 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.26 Pain Relevance 0.64
Similar mRNA increases were observed after inflammation in knockout mice: ASIC2 mRNA increases in ASIC3-/- mice; ASIC2 and ASIC3 mRNAs increase in ASIC1-/- mice.
Positive_regulation (increases) of Positive_regulation (increase) of ASIC1 associated with targeted disruption and inflammation
2) Confidence 0.49 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.47 Pain Relevance 0.85
TBOA led to an increase in the amplitude of the aSIC by 112.1 ± 31.7 pA (Fig. 3, B and C).
Positive_regulation (led) of Positive_regulation (increase) of aSIC associated with asic
3) Confidence 0.05 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0.06 Pain Relevance 0.40

General Comments

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