INT165085

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.65
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
Muscle 2
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 99.98 Very High Very High Very High
Root ganglion neuron 2 96.48 Very High Very High Very High
Hyperalgesia 22 92.80 High High
ASIC 8 90.04 High High
nociceptor 4 25.00 Low Low
IPN 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.98 Very High Very High Very High
Targeted Disruption 2 99.64 Very High Very High Very High
Ganglion Cysts 2 96.16 Very High Very High Very High
Hyperalgesia 22 93.60 High High
Acidosis 2 90.88 High High
Injury 6 87.04 High High
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Neg (not) Positive_regulation (causes) of Neg (not) Positive_regulation (increases) of ASIC3 in Muscle associated with inflammation
1) Confidence 0.48 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.19 Pain Relevance 0.58
Similar mRNA increases were observed after inflammation in knockout mice: ASIC2 mRNA increases in ASIC3-/- mice; ASIC2 and ASIC3 mRNAs increase in ASIC1-/- mice.
Positive_regulation (increases) of Positive_regulation (increase) of ASIC3 associated with targeted disruption and inflammation
2) Confidence 0.48 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.47 Pain Relevance 0.85

General Comments

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