INT165104

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.21
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
blood 2
hepatocyte 2
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 21 98.36 Very High Very High Very High
cytokine 5 97.56 Very High Very High Very High
addiction 2 95.04 Very High Very High Very High
Spinal cord 34 94.40 High High
Paracetamol 4 93.60 High High
Dorsal horn 2 70.92 Quite High
Inflammation 22 63.92 Quite High
Kinase C 3 61.32 Quite High
Dorsal horn neuron 3 56.24 Quite High
imagery 2 40.80 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 25 100.00 Very High Very High Very High
Death 23 99.92 Very High Very High Very High
Smoke Inhalation Injury 15 99.56 Very High Very High Very High
Diabetes Mellitus 17 99.36 Very High Very High Very High
Apoptosis 68 99.16 Very High Very High Very High
Lung Cancer 10 98.68 Very High Very High Very High
Pain 23 98.36 Very High Very High Very High
Stress 15 97.00 Very High Very High Very High
Injury 30 94.48 High High
Sprains And Strains 57 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, blockade of JNK using a selective agent reduced late phase formalin licking behavior.
Negative_regulation (reduced) of Negative_regulation (blockade) of JNK
1) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.39 Pain Relevance 0.42
Although the JNK inhibitor was introduced 1 h after smoke inhalation injury, we still observed a decrease in mucus production.
Negative_regulation (introduced) of Negative_regulation (inhibitor) of JNK associated with smoke inhalation injury
2) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.59 Pain Relevance 0.08
Inhibition of JNK using chemical inhibitors or knocking down JNK can prevent hepatocyte death even in the presence of extensive glutathione (GSH) depletion, covalent binding, and oxidative stress.
Negative_regulation (knocking) of Negative_regulation (Inhibition) of JNK in hepatocyte associated with stress and death
3) Confidence 0.38 Published 2010 Journal Handb Exp Pharmacol Section Abstract Doc Link 20020266 Disease Relevance 1.50 Pain Relevance 0.19
Thus, inhibition of JNK dramatically improves insulin resistance and markedly decreases blood glucose levels.
Negative_regulation (decreases) of Negative_regulation (inhibition) of JNK in blood associated with insulin resistance
4) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.72 Pain Relevance 0.08
In our model system inhibition of the JNK pathway particularly decreased the gemcitabine dependent cell death.
Negative_regulation (decreased) of Negative_regulation (inhibition) of JNK associated with death
5) Confidence 0.20 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 1.00 Pain Relevance 0

General Comments

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