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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.45
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
hepatocyte 1
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 54 98.24 Very High Very High Very High
cytokine 55 95.04 Very High Very High Very High
Inflammation 73 85.12 High High
Paracetamol 6 85.08 High High
Kinase C 5 69.56 Quite High
ketamine 3 27.40 Quite Low
anesthesia 2 26.20 Quite Low
Taxol 1 18.32 Low Low
rheumatoid arthritis 33 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 47 100.00 Very High Very High Very High
Cancer 77 99.84 Very High Very High Very High
Stress 16 99.28 Very High Very High Very High
Arthritis 64 98.24 Very High Very High Very High
Apoptosis 69 97.62 Very High Very High Very High
Death 26 96.48 Very High Very High Very High
Osteoporosis 4 96.08 Very High Very High Very High
Retinoblastoma 1 95.52 Very High Very High Very High
Necrosis 9 87.00 High High
Injury 32 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide.

Localization (cause) of JNK associated with cancer and hepatocellular cancer
1) Confidence 0.69 Published 2010 Journal Gastroenterology Research and Practice Section Title Doc Link PMC2995932 Disease Relevance 0.73 Pain Relevance 0.12
Western blot analysis was carried out as previously described for phosphorylated and dephosphorylated (total) forms of p38 MAPK and JNK [18], [19].
Localization (forms) of JNK
2) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.30 Pain Relevance 0.04
Once activated, JNK translocates to mitochondria, to induce mitochondria permeability transition and trigger hepatocyte death.
Localization (translocates) of JNK in hepatocyte associated with death
3) Confidence 0.63 Published 2010 Journal Handb Exp Pharmacol Section Abstract Doc Link 20020266 Disease Relevance 1.52 Pain Relevance 0.17
Prostate apoptosis response (PAR) – 4 appears to supplement JNK activity as loss of this protein caused hyperactivation of NF-kappaB and impairment of JNK and p38 [63].
Neg (impairment) Localization (impairment) of JNK associated with apoptosis
4) Confidence 0.59 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.74 Pain Relevance 0.03
B translocation and inhibits c-Jun N-terminal kinase
Localization (translocation) of c-Jun N-terminal kinase
5) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.93 Pain Relevance 0.39
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Localization (determination) of JNK
6) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
and c-Jun (a phosphorylation target of ERK and JNK).
Localization (target) of JNK
7) Confidence 0.27 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1082887 Disease Relevance 0.17 Pain Relevance 0

General Comments

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