INT165153

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.17
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gli1) intracellular (Gli1) cilium (Gli1)
DNA binding (Gli1) cytoplasm (Gli1) cytosol (Gli1)
Anatomy Link Frequency
mesenchyme 1
Gli1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 98.48 Very High Very High Very High
Potency 2 88.72 High High
melanocortin 1 receptor 1 82.92 Quite High
Enkephalin 2 25.00 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 48 99.30 Very High Very High Very High
Targeted Disruption 2 96.40 Very High Very High Very High
Aplasia 2 87.40 High High
Malignant Neoplastic Disease 1 65.48 Quite High
Disease 2 44.32 Quite Low
Sunburn 23 23.12 Low Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Cleft Palate 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analyses of activated IHH signaling in C3H10T1/2 cells showed that three BDA1-associated mutations (p.E95K, p.D100E and p.E131K) severely impaired the induction of targets such as Ptch1 and Gli1.
Positive_regulation (induction) of Gli1
1) Confidence 0.59 Published 2010 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 20024692 Disease Relevance 0.09 Pain Relevance 0.07
Dysregulation of the Sonic hedgehog signal transduction pathway plays an important role in the pathogenesis of BCC, presumably based on constitutive activation of GLI family transcription factors [6-8].
Positive_regulation (activation) of GLI associated with skin cancer
2) Confidence 0.45 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2789726 Disease Relevance 1.02 Pain Relevance 0.08
In turn, epithelial Shh signals to the underneath mesenchyme where target genes like Gli1 and Ptc are induced [23].
Positive_regulation (induced) of Gli1 in mesenchyme
3) Confidence 0.43 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
Penk1 and Igfbp5 were confirmed to be regulated by GLI1, while the induction of Sostdc1 by IHH is independent of GLI1.
Neg (independent) Positive_regulation (independent) of GLI1
4) Confidence 0.43 Published 2010 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 20024692 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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