INT165182

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 4.29
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry12) mitochondrion (P2ry12) plasma membrane (P2ry12)
signal transducer activity (P2ry12)
Anatomy Link Frequency
microglia 3
sensory neurons 2
dorsal root ganglia 2
P2ry12 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 96 100.00 Very High Very High Very High
intrathecal 5 99.30 Very High Very High Very High
Neuropathic pain 13 98.96 Very High Very High Very High
hyperexcitability 2 98.64 Very High Very High Very High
Pain 14 97.60 Very High Very High Very High
MU agonist 10 97.48 Very High Very High Very High
Dorsal horn neuron 6 97.20 Very High Very High Very High
nociceptor 85 96.36 Very High Very High Very High
antagonist 37 94.80 High High
imagery 45 94.12 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 98.96 Very High Very High Very High
Pain 29 97.60 Very High Very High Very High
Nociception 155 96.96 Very High Very High Very High
INFLAMMATION 101 93.20 High High
Injury 36 92.16 High High
Nervous System Injury 13 91.88 High High
Inflammatory Pain 11 50.00 Quite Low
Hyperalgesia 80 44.88 Quite Low
Bordatella Infection 15 5.00 Very Low Very Low Very Low
Overdose 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from these P2Y family members, P2RY12 was also reported to be selectively expressed in microglia in the rat brain [32].
Gene_expression (expressed) of P2RY12 in microglia
1) Confidence 0.65 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.18
Intriguingly, these authors also demonstrated that intrathecal administration of a non-selective agonist of P2Y1, P2Y12 and P2Y13 (ADP-?
Gene_expression (agonist) of P2Y12 associated with agonist and intrathecal
2) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.35 Pain Relevance 0.50
It is possible that extensive co-expression of P2Y12 with P2Y13 in sensory neurons, both of which are Gi/o-coupled ADP receptors, prevents pro-nociceptive consequences of peripheral P2Y12 antagonism in experimental models and in patients using clopidogrel.
Gene_expression (-) of P2Y12 in sensory neurons associated with nociception
3) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.61 Pain Relevance 0.35
Here, we demonstrate that P2Y12, P2Y13 and P2Y14 are all expressed in sensory neurons of the dorsal root ganglia (DRG) with neurochemical characteristics of nociceptors.
Gene_expression (expressed) of P2Y12 in dorsal root ganglia associated with nociceptor
4) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.30 Pain Relevance 0.45
It is possible that extensive co-expression of P2Y12 with P2Y13 in sensory neurons, both of which are Gi/o-coupled ADP receptors, prevents pro-nociceptive consequences of peripheral P2Y12 antagonism in experimental models and in patients using clopidogrel.
Gene_expression (expression) of P2Y12 in sensory neurons associated with nociception
5) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.61 Pain Relevance 0.35
Expression of mRNA for all three of the Gi-coupled P2Y receptors was identified in mouse lumbar DRG by real-time PCR, with relative levels of expression of P2Y12 ~P2Y14 > P2Y13 (Table 1).
Gene_expression (expression) of P2Y12 in DRG
6) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.48 Pain Relevance 0.47
Activated spinal microglia also express P2Y12R, and P2Y12R-KO mice display impaired neuropathic pain.
Gene_expression (express) of P2Y12R in microglia associated with neuropathic pain
7) Confidence 0.07 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 20030208 Disease Relevance 0.90 Pain Relevance 0.90
Activated spinal microglia also express P2Y12R, and P2Y12R-KO mice display impaired neuropathic pain.
Gene_expression (express) of P2Y12R in microglia associated with neuropathic pain
8) Confidence 0.06 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 20030208 Disease Relevance 0.90 Pain Relevance 0.90

General Comments

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