INT1652

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Context Info
Confidence 0.62
First Reported 1977
Last Reported 2010
Negated 77
Speculated 33
Reported most in Abstract
Documents 387
Total Number 420
Disease Relevance 61.01
Pain Relevance 186.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
brain 50
plasma 45
pituitary 29
hypothalamus 26
arcuate nucleus 10
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 391 100.00 Very High Very High Very High
Morphine 386 100.00 Very High Very High Very High
Opioid 353 100.00 Very High Very High Very High
narcan 333 100.00 Very High Very High Very High
Dynorphin 173 100.00 Very High Very High Very High
opiate 171 100.00 Very High Very High Very High
antagonist 157 100.00 Very High Very High Very High
Pain 129 100.00 Very High Very High Very High
Neuropeptide 116 100.00 Very High Very High Very High
opioid receptor 101 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 284 100.00 Very High Very High Very High
Stress 151 100.00 Very High Very High Very High
Pain 128 100.00 Very High Very High Very High
Obesity 102 100.00 Very High Very High Very High
Urological Neuroanatomy 92 100.00 Very High Very High Very High
Nociception 49 100.00 Very High Very High Very High
Shock 48 100.00 Very High Very High Very High
Diabetes Mellitus 40 100.00 Very High Very High Very High
Lordosis 22 100.00 Very High Very High Very High
Sleep Disorders 9 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While ethanol treatment did not affect proopiomelanocortin mRNA levels in the pituitary, the level in hypothalamus was significantly lower in the ethanol-treated animals than in controls.
Neg (not) Regulation (affect) of proopiomelanocortin mRNA in pituitary
1) Confidence 0.62 Published 1992 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 1471770 Disease Relevance 0.10 Pain Relevance 0.17
Treatment with the peripheral vasodilator hydralazine, 2 mg/kg/day, does not affect POMC mRNA levels.
Neg (not) Regulation (affect) of POMC mRNA
2) Confidence 0.62 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8677016 Disease Relevance 0.28 Pain Relevance 0.10
In order to investigate the role of opiates in the regulation of POMC gene expression in the rat arcuate nucleus, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on POMC mRNA levels as measured by in situ hybridization, 4-day treatment with naloxone (4 mg/kg/day) produced a 60% increase in the number of silver grains overlying POMC neurons.
Regulation (effects) of POMC mRNA in neurons associated with antagonist, narcan, opiate, opioid and morphine
3) Confidence 0.62 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8413862 Disease Relevance 0 Pain Relevance 1.10
Similarly, POMC mRNA levels in the intermediate/posterior pituitary were also not significantly altered during exposure to repeated stress.
Neg (not) Regulation (altered) of POMC mRNA in posterior pituitary associated with stress
4) Confidence 0.62 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2942792 Disease Relevance 0.65 Pain Relevance 0.09
To test whether the decline in melatonin is responsible for the decline in POMC mRNA, we investigated the effects of daily melatonin treatment on hypothalamic POMC mRNA content in middle-aged and older Sprague-Dawley rats.
Spec (investigated) Regulation (effects) of POMC mRNA
5) Confidence 0.62 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12562504 Disease Relevance 0.17 Pain Relevance 0.09
The aim of the present study was to evaluate the effect of a 2-week oral treatment with drospirenone, estradiol valerate, and combined therapy of drospirenone + estradiol valerate on central and peripheral beta-endorphin and allopregnanolone levels in ovariectomized female rats.
Regulation (effect) of beta-endorphin
6) Confidence 0.62 Published 2007 Journal Menopause Section Abstract Doc Link 17075429 Disease Relevance 0 Pain Relevance 0.14
Effect of isolation conditions on brain regional enkephalin and beta-endorphin levels and vocalizations in 10-day-old rat pups.
Regulation (Effect) of beta-endorphin in brain associated with enkephalin
7) Confidence 0.61 Published 1995 Journal Behav. Neurosci. Section Title Doc Link 7734067 Disease Relevance 0 Pain Relevance 0.64
Effect of chronic acamprosate treatment on voluntary alcohol intake and beta-endorphin plasma levels in rats selectively bred for high alcohol preference.
Regulation (Effect) of beta-endorphin in plasma associated with alcohol
8) Confidence 0.61 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18162308 Disease Relevance 0.14 Pain Relevance 0.35
Retrieval effects of beta-endorphin and naloxone, and the novelty-induced antinociception in the developing rat.
Regulation (effects) of beta-endorphin associated with antinociception and narcan
9) Confidence 0.61 Published 1991 Journal Behav. Neural Biol. Section Title Doc Link 2059193 Disease Relevance 0.05 Pain Relevance 0.58
Chronic treatment with CP-55,940 regulates corticotropin releasing factor and proopiomelanocortin gene expression in the hypothalamus and pituitary gland of the rat.
Regulation (regulates) of corticotropin in hypothalamus associated with cannabinoid
10) Confidence 0.61 Published 1999 Journal Life Sci. Section Title Doc Link 10201639 Disease Relevance 0 Pain Relevance 0.29
Reexposure to the experimental chamber only affected beta-endorphin levels if shock had been experienced in this chamber.
Regulation (affected) of beta-endorphin associated with shock
11) Confidence 0.61 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1871193 Disease Relevance 0.78 Pain Relevance 0.38
In the nucleus accumbens, 0.5 and 2 microM 5-HT in the perfusion fluid did not affect the levels of beta-endorphin in the dialysate, whereas 5 and 10 microM 5-HT caused an increase of approximately 190% of baseline.
Neg (not) Regulation (affect) of beta-endorphin in nucleus accumbens associated with nucleus accumbens
12) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10582620 Disease Relevance 0.06 Pain Relevance 0.64
Lack of changes in beta-endorphin plasma levels after repeated treatment with fluoxetine: possible implications for the treatment of alcoholism--a pilot study.
Regulation (changes) of beta-endorphin in plasma associated with alcohol addiction and fluoxetine
13) Confidence 0.61 Published 2008 Journal Pharmazie Section Title Doc Link 18468392 Disease Relevance 0.10 Pain Relevance 0.81
In contrast, neither beta-endorphin nor food deprivation analgesia is affected by aging.
Neg (neither) Regulation (affected) of beta-endorphin associated with aging and analgesia
14) Confidence 0.61 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3066444 Disease Relevance 0.49 Pain Relevance 1.16
The aim of the present study in alcohol-preferring rats (Warsaw High Preferring; WHP) was to investigate the effect of 10 days of naltrexone treatment (2 mg/kg i.p.) on voluntary alcohol intake and on changes in plasma beta-endorphin levels while alcohol was available and 10 days after imposed abstinence.
Regulation (changes) of beta-endorphin in plasma associated with alcohol
15) Confidence 0.61 Published 2008 Journal Physiol. Behav. Section Abstract Doc Link 18262210 Disease Relevance 0.08 Pain Relevance 0.74
Repeated administration of delta9-tetrahydrocannabinol produces a differential time related responsiveness on proenkephalin, proopiomelanocortin and corticotropin releasing factor gene expression in the hypothalamus and pituitary gland of the rat.
Regulation (responsiveness) of corticotropin in hypothalamus associated with enkephalin
16) Confidence 0.61 Published 1999 Journal Neuropharmacology Section Title Doc Link 10219981 Disease Relevance 0.07 Pain Relevance 0.28
Chronic treatment (18 days) with desipramine or paroxetine did not significantly affect the extracellular levels of beta-endorphin in the NAcc of either the FSL or control rats.
Neg (not) Regulation (affect) of beta-endorphin in NAcc associated with nucleus accumbens and desipramine
17) Confidence 0.61 Published 2002 Journal Neuroscience Section Abstract Doc Link 11906780 Disease Relevance 0.40 Pain Relevance 0.78
The effects of opioid peptides on a 1.1-kb long proopiomelanocortin messenger RNA (POMC mRNA) have been investigated in rat hypothalamic cells maintained in culture.
Regulation (effects) of proopiomelanocortin messenger RNA associated with opioid
18) Confidence 0.61 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1649365 Disease Relevance 0 Pain Relevance 0.67
The effects of opioid peptides on a 1.1-kb long proopiomelanocortin messenger RNA (POMC mRNA) have been investigated in rat hypothalamic cells maintained in culture.
Regulation (effects) of POMC mRNA associated with opioid
19) Confidence 0.61 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1649365 Disease Relevance 0 Pain Relevance 0.67
Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells.
Regulation (regulation) of pro-opiomelanocortin in AtT20 associated with narcan and opioid
20) Confidence 0.61 Published 2001 Journal Neuroendocrinology Section Title Doc Link 11474216 Disease Relevance 0 Pain Relevance 0.87

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