INT165212

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
B-cell 2
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 25 50.00 Quite Low
cINOD 3 50.00 Quite Low
imagery 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 36 99.00 Very High Very High Very High
Hypoxia 77 98.80 Very High Very High Very High
Macroglobulinemia 14 97.72 Very High Very High Very High
Disease 7 84.16 Quite High
Bordatella Infection 3 73.00 Quite High
Adhesions 35 62.64 Quite High
Cancer 145 50.00 Quite Low
Metastasis 131 50.00 Quite Low
Breast Cancer 38 50.00 Quite Low
Colon Cancer 25 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
signaling pathways regulates VEGF and CXCR4 mRNA expression and promoter activation.


Regulation (regulates) of Gene_expression (expression) of CXCR4 mRNA
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.54 Pain Relevance 0
The expression of CXCR4, a receptor involved in B-cell trafficking and homing, was found to be down regulated in WM compared to other NHL types, thus suggesting a possible role of CXCR4 in WM cell homing in the BM.
Regulation (regulated) of Gene_expression (expression) of CXCR4 in B-cell associated with lymphatic system cancer
2) Confidence 0.25 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2995803 Disease Relevance 0.65 Pain Relevance 0
CXCL12, CXCR4 and CXCR7 expression were amplified using 33 cycles of 94°C for 30 sec, 60°C for 30 sec, and 72°C for 30 sec.
Regulation (amplified) of Gene_expression (expression) of CXCR4
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.14 Pain Relevance 0
This effect was unrelated to changes on expression of CD4, CXCR4, cell viability or activation.
Regulation (changes) of Gene_expression (expression) of CXCR4
4) Confidence 0.08 Published 2009 Journal Antivir. Ther. (Lond.) Section Body Doc Link 20032540 Disease Relevance 0 Pain Relevance 0

General Comments

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