INT165213

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.14
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 13
B lymphocytes 2
nerve 2
MR1 2
memory T cell 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 43 98.24 Very High Very High Very High
Demyelination 5 96.72 Very High Very High Very High
cytokine 100 94.72 High High
Arthritis 59 92.52 High High
dorsal root ganglion 55 91.28 High High
Inflammation 84 90.96 High High
Central nervous system 49 87.44 High High
withdrawal 2 86.56 High High
Multiple sclerosis 37 82.36 Quite High
chemokine 13 70.00 Quite High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 90 99.98 Very High Very High Very High
Cold Sores 367 99.44 Very High Very High Very High
Systemic Lupus Erythematosus 1 99.16 Very High Very High Very High
Ocular Injury 29 98.86 Very High Very High Very High
Infection 156 98.68 Very High Very High Very High
Rheumatoid Arthritis 43 98.24 Very High Very High Very High
Disease 142 97.60 Very High Very High Very High
Enzootic Bovine Leukosis 2 97.52 Very High Very High Very High
Demyelinating Disease 35 96.72 Very High Very High Very High
Hepatitis C Virus Infection 103 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the MR1 mAb targets the interaction between CD4+ T cells and APCs, we next analyzed its effect on transferred HNT CD4+ T cells.
Spec (analyzed) Regulation (effect) of Gene_expression (transferred) of CD4 in MR1
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.07 Pain Relevance 0
This result suggests that a penetrating ocular injury at an early stage after an AC injection of OVA does not alter the expression of CD4+CD25+Foxp3+T cells and thereby does not result in the induction of ACAID.
Neg (not) Regulation (alter) of Gene_expression (expression) of CD4+ in T cells associated with ocular injury
2) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.60 Pain Relevance 0.03
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Regulation (repetitive) of Gene_expression (expression) of CD4 in T cells
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.66 Pain Relevance 0.18
F protein elicited specific CD4+ T cell response in chronic infected patients
Regulation (specific) of Gene_expression (response) of CD4 in T cell
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.87 Pain Relevance 0
In particular, transcriptional regulation of CD4 silencer and Th-POK have been described in detail [13,15].
Regulation (regulation) of Gene_expression (silencer) of CD4
5) Confidence 0.33 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.02 Pain Relevance 0.16
was shown to control the CD4+ memory T cell reservoir mostly in the context of a second genetic alteration (MRL-lpr or p65PI3KTg), while single-targeted PI3K?
Regulation (control) of Gene_expression (reservoir) of CD4 in memory T cell
6) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.42 Pain Relevance 0.11
Interestingly, the importance of TNF signaling in mediating nerve demyelination was found to occur independently of the adaptive immune response as the Tg6074 line of TNF overexpressing mice, even when backcrossed to mice deficient in CD4 (to ablate CD4+ lympocytes), ?
Regulation (ablate) of Gene_expression (lympocytes) of CD4 in nerve associated with demyelination
7) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.65 Pain Relevance 0.33
We thus have chosen to test the anti-CMV CD4pos T-cell response as a model for the study of the antiviral response in RA patients whose TNF-?
Regulation (model) of Gene_expression (response) of CD4pos in T-cell associated with rheumatoid arthritis and cytomegalovirus infection
8) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945035 Disease Relevance 1.73 Pain Relevance 0.32
-retroviruses infecting CD4+ in humans and B lymphocytes in ruminants, respectively [15].
Regulation (retroviruses) of Gene_expression (infecting) of CD4 in B lymphocytes
9) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736388 Disease Relevance 1.18 Pain Relevance 0
production and the presence of CD4+ and CD8+ T cells are key regulators of viral clearance during acute infection.
Regulation (regulators) of Gene_expression (production) of CD4 in T cells associated with infection
10) Confidence 0.15 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.28 Pain Relevance 0.34
The clinical significance of the increase in CD4 T lymphocytes that are produced under the influence of IL-2 therapy is uncertain and has led to the initiation of two large clinical endpoint studies (SILCAAT and ESPRIT [31]) to assess the clinical consequences of IL-2 in combination with antiretroviral therapy.
Regulation (under) of Gene_expression (produced) of CD4 in T lymphocytes
11) Confidence 0.11 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488892 Disease Relevance 0.51 Pain Relevance 0
Salp15 inhibits CD4+ T cells activation as well as IL-2 production [9], which can down-regulate Th1 response and therefore macrophage activity.
Regulation (regulate) of in T cells Gene_expression (activation) of CD4 in macrophage
12) Confidence 0.06 Published 2009 Journal Veterinary Research Section Body Doc Link PMC2701186 Disease Relevance 0.15 Pain Relevance 0.09
This effect was unrelated to changes on expression of CD4, CXCR4, cell viability or activation.
Regulation (changes) of Gene_expression (expression) of CD4
13) Confidence 0.04 Published 2009 Journal Antivir. Ther. (Lond.) Section Body Doc Link 20032540 Disease Relevance 0 Pain Relevance 0

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