INT165228

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 13
Total Number 19
Disease Relevance 25.36
Pain Relevance 7.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
knee 6
joint 3
chondrocyte 1
spinal 1
hip 1
BMI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 466 100.00 Very High Very High Very High
backache 7 99.92 Very High Very High Very High
Osteoarthritis 563 99.60 Very High Very High Very High
spinal stenosis 1 97.20 Very High Very High Very High
Inflammation 16 94.24 High High
rheumatoid arthritis 11 94.16 High High
Facet joint 1 94.16 High High
imagery 14 73.36 Quite High
Arthritis 16 57.44 Quite High
palliative 6 41.16 Quite Low
Disease Link Frequency Relevance Heat
Obesity 832 100.00 Very High Very High Very High
Pain 454 100.00 Very High Very High Very High
Low Back Pain 10 99.92 Very High Very High Very High
Frailty 178 99.60 Very High Very High Very High
Body Weight 13 99.00 Very High Very High Very High
Knee Osteoarthritis 195 98.90 Very High Very High Very High
Cancer 89 97.96 Very High Very High Very High
Spinal Stenosis 1 97.20 Very High Very High Very High
Hip Osteoarthritis 90 96.48 Very High Very High Very High
Spondylolysis 1 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used linear regression models to examine the association of paraspinal muscles density with age, sex, BMI, LBP, and spinal degeneration features.
BMI Spec (examine) Binding (association) of in spinal associated with backache
1) Confidence 0.47 Published 2010 Journal Eur Spine J Section Abstract Doc Link 20033739 Disease Relevance 1.25 Pain Relevance 0.71
To address the potential for confounding when assessing the association between BMI and knee pain, we ran an adjusted statistical model (Pain = BMI + age + gender + RKOA grade).
BMI Binding (association) of in knee associated with pain, obesity and osteoarthritis
2) Confidence 0.36 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.22 Pain Relevance 0.77
However, other investigators have discounted this notion, concluding there is "no evidence that the association between BMI and knee OA is stronger for those with knee symptoms" [9].
BMI Neg (no) Binding (association) of in knee associated with obesity and osteoarthritis
3) Confidence 0.36 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.99 Pain Relevance 1.29
In the same line, co-labeling experiments with CTIP2 and CSC marker BMI1 highlighted the existence of a distinct subset of cancer cells (BMI1+/CTIP2+) with possible stem cell characteristics.
BMI1 Binding (experiments) of in stem cell associated with cancer
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.54 Pain Relevance 0
With BMI as the exposure factor, subjects with normal BMI (18.5 to 24.9 kg/m2) served as the reference group for the analyses (e.g.
BMI Spec (analyses) Binding (served) of associated with obesity
5) Confidence 0.28 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.60 Pain Relevance 0.76
Using a sample of subjects with RKOA, our cross-sectional study [17] seeks to quantify the association between BMI and knee pain among subjects with radiographic evidence of knee OA.


BMI Binding (association) of in knee associated with pain, obesity and osteoarthritis
6) Confidence 0.27 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.03 Pain Relevance 0.96
To estimate the strength of the association between BMI and knee pain, we computed odds ratios (OR) [22] using multiple logistic regression [23,24].
BMI Binding (association) of in knee associated with pain and obesity
7) Confidence 0.27 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.59 Pain Relevance 0.87
Odds ratios for the association between BMI and knee pain are presented in Table 3.
BMI Binding (association) of in knee associated with pain and obesity
8) Confidence 0.27 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.22 Pain Relevance 0.92
This observation is further supported by the study of Stickles et al. [26], who observed an association between BMI and problems climbing stairs 1 year after total joint arthroplasty.
BMI Binding (association) of in joint
9) Confidence 0.18 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.14 Pain Relevance 0.39
There is also a weak association between pain in the hip and BMI [27], and evidence that body weight and BMI are significant predictors of the onset of OA of the hip [5].
BMI Binding (association) of in hip associated with pain, body weight and osteoarthritis
10) Confidence 0.14 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.27 Pain Relevance 0.40
A second multivariate model with only PC1 of the knee adduction moment and BMI showed that BMI was no longer significantly associated?
BMI Binding (associated) of in knee
11) Confidence 0.13 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0 Pain Relevance 0
BMI was associated with log MTPM at 6 months (r2 = 0.14 (0.004–0.40), p = 0.02), but the correlation was not statistically significant with the Bonferroni correction.
BMI Binding (associated) of
12) Confidence 0.13 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0 Pain Relevance 0
A secondary objective was to examine the multivariate association between preoperative joint loading and BMI on the one hand and post-TKA implant migration on the other.


BMI Spec (examine) Binding (association) of in joint
13) Confidence 0.10 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0.52 Pain Relevance 0.11
The most important conclusion from our work is the recognition of a multivariate statistical association between joint loading during gait and BMI with implant migration.
BMI Binding (association) of in joint
14) Confidence 0.10 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0.48 Pain Relevance 0.08
Preoperative gait patterns and BMI are associated with tibial component migration

Background and purpose

BMI Binding (associated) of
15) Confidence 0.10 Published 2010 Journal Acta Orthopaedica Section Title Doc Link PMC2917572 Disease Relevance 0.14 Pain Relevance 0
After adjusting for confounding factors that included gender, age, age when left school, type of work and five obesity-related morbidities, the association between BMI and HRQoL was statistically significant.
BMI Binding (association) of associated with obesity
16) Confidence 0.04 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2788145 Disease Relevance 1.16 Pain Relevance 0
This analysis of data from the HSE 2003 shows that in the general adult population of England, there is a strong association between BMI above normal (and below normal) and decreased HRQoL.
BMI Binding (association) of associated with obesity
17) Confidence 0.04 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2788145 Disease Relevance 1.85 Pain Relevance 0.16
BMI = body mass index; CRP = C-reactive protein; CV = coefficient of variation; hsCRP = high sensitivity CRP; IL = interleukin; ln = natural log; OA = osteoarthritis; RA = rheumatoid arthritis; SD = standard deviation; TNF?
BMI Binding (index) of in body associated with obesity, rheumatoid arthritis and osteoarthritis
18) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 1.45 Pain Relevance 0.54
The lack of a marked effect of leptin at 20 ng/ml also explains the lack of any association between chondrocyte response to the adipokine and BMI.
BMI Binding (association) of in chondrocyte associated with obesity
19) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.90 Pain Relevance 0.03

General Comments

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