INT165275

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.83
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cfb) peptidase activity (Cfb) extracellular space (Cfb)
extracellular region (Cfb)
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
narcan 1 100.00 Very High Very High Very High
antinociception 3 98.96 Very High Very High Very High
Analgesic 4 92.04 High High
rheumatoid arthritis 18 89.76 High High
Inflammation 30 88.24 High High
Antinociceptive 2 79.84 Quite High
antagonist 4 79.12 Quite High
Opioid 1 51.40 Quite High
ischemia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paroxysmal Nocturnal Hemoglobinuria 3 95.04 Very High Very High Very High
Systemic Lupus Erythematosus 18 90.96 High High
Nociception 1 90.68 High High
Renal Disease 6 90.56 High High
Rheumatoid Arthritis 18 89.76 High High
Disease 45 88.60 High High
INFLAMMATION 36 88.24 High High
Stress 1 71.64 Quite High
Targeted Disruption 18 62.52 Quite High
American Trypanosomiasis 3 31.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reconstitution of the alternative C3 convertase (C3bBb) in vitro from purified C3b, fB and fD (but not properdin) was not affected by SGE.
Neg (not) Regulation (affected) of properdin
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice.
Regulation (Effects) of A/B associated with antinociception and narcan
2) Confidence 0.04 Published 2010 Journal Peptides Section Title Doc Link 20035812 Disease Relevance 0.09 Pain Relevance 0.90
As compared to these inhibitors, IxACs have a completely new action mechanism as they bind and prevent the action of properdin, a factor that has not yet been found to be negatively regulated.
Regulation (regulated) of properdin
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.54 Pain Relevance 0.13
Anticomplement proteins from I. ricinus are the first inhibitors that specifically target a positive regulator of complement, properdin.
Regulation (target) of properdin
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2151134 Disease Relevance 0.06 Pain Relevance 0.03
Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.
Regulation (regulate) of and B
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.13 Pain Relevance 0

General Comments

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