INT16528

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1984
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.37
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 4
plasma 2
brain 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 13 99.98 Very High Very High Very High
Clonidine 7 99.32 Very High Very High Very High
antagonist 1 96.88 Very High Very High Very High
agonist 2 85.92 High High
anesthesia 3 81.72 Quite High
opiate 1 79.68 Quite High
Serotonin 1 79.24 Quite High
monoamine 1 67.60 Quite High
Central nervous system 1 28.00 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 1 86.04 High High
Obesity 2 75.00 Quite High
Pancreatic Cancer 1 74.00 Quite High
Weight Gain 1 73.68 Quite High
Panic Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate that alprazolam, but not diazepam, activates brain alpha 2-adrenoceptors involved in rat GH regulation.
Positive_regulation (activates) of Regulation (regulation) of GH in brain
1) Confidence 0.48 Published 1986 Journal Life Sci. Section Abstract Doc Link 2871466 Disease Relevance 0 Pain Relevance 0.37
However, a significantly blunted GH response to both doses of rGRF occurred only in group II.
Positive_regulation (blunted) of Regulation (response) of GH
2) Confidence 0.44 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2145525 Disease Relevance 0.30 Pain Relevance 0.08
Administration of antiserum against somatostatin (1 ml) plus chlorpromazine significantly elevated the basal plasma GH level and GH response to arginine in control rats, but did not elevate them in VMH lesioned rats.
Positive_regulation (elevated) of Regulation (response) of GH in plasma associated with somatostatin
3) Confidence 0.41 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.44
Reduction of both GRF and somatostatin caused blunted spontaneous GH secretion and normal GH response to arginine and clonidine.
Positive_regulation (caused) of Regulation (response) of GH associated with somatostatin and clonidine
4) Confidence 0.41 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.44
Results showed that (a) pituitary responsiveness to GHRH changes throughout the estrous cycle is maximal in diestrus and minimal in proestrus; (b) GHRH stimulated GH secretion in intact and ovariectomized females on days 45, 60 and 90, but not on day 30; (c) the age increase of GH responsiveness to GHRH administration was slightly reduced in animals ovariectomized on day 23; (e) the age increase of pituitary GH content was similar in control and ovariectomized females; and (d) ovariectomy on day 83 reduced pituitary responsiveness to GHRH more effectively than ovariectomy on day 23.
Positive_regulation (increase) of Regulation (responsiveness) of GH in pituitary
5) Confidence 0.40 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1834957 Disease Relevance 0 Pain Relevance 0.07
These data indicate that GH responsiveness to hpGRF is: enhanced in the anterior pituitary shortly after hypothalamo-pituitary disconnection and, despite a striking reduction of the pituitary GH stores, it is maintained after these lesions.
Positive_regulation (enhanced) of Regulation (responsiveness) of GH in pituitary
6) Confidence 0.26 Published 1984 Journal Life Sci. Section Abstract Doc Link 6436609 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox