INT165280

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tnf, Nos2) extracellular space (Tnf, Nos2) signal transduction (Tnf, Nos2)
peroxisome (Nos2) extracellular matrix organization (Tnf) cytoplasm (Nos2)
Anatomy Link Frequency
SCs 2
Tnf (Mus musculus)
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 10 100.00 Very High Very High Very High
Inflammation 2 100.00 Very High Very High Very High
cytokine 1 51.96 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 10 100.00 Very High Very High Very High
INFLAMMATION 2 100.00 Very High Very High Very High
Demyelinating Disease 1 56.08 Quite High
Necrosis 1 49.24 Quite Low
Cancer 1 48.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest that TNF-alpha may exert pro-inflammatory effects in EAN via TNFR1 by up-regulating the antigen-presenting function and iNOS production of SCs.
TNF-alpha Positive_regulation (up-regulating) of Gene_expression (production) of iNOS in SCs associated with inflammation and neuritis
1) Confidence 0.24 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20035831 Disease Relevance 1.02 Pain Relevance 0.91

General Comments

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