INT165285

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.84
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts, Crh) extracellular space (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
spinal cord 2
Nts (Mus musculus)
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 96.24 Very High Very High Very High
analgesia 20 95.64 Very High Very High Very High
Opioid 10 95.48 Very High Very High Very High
Pain 22 93.88 High High
antinociception 2 89.48 High High
agonist 2 79.64 Quite High
antagonist 2 59.60 Quite High
Analgesic 2 33.24 Quite Low
narcan 2 32.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 24 99.48 Very High Very High Very High
Pain 16 93.88 High High
Hyperalgesia 2 61.04 Quite High
Targeted Disruption 2 50.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results also revealed that the release of endogenous NT in response to stress requires the presence of NTS2 to stimulate corticotropin-releasing factor (CRF)-induced elevation of plasma corticosterone, and that NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.
NTS2 Positive_regulation (stimulate) of CRF in spinal cord associated with stress, pain and spinal cord
1) Confidence 0.40 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 0.92 Pain Relevance 0.96
Our results also revealed that the release of endogenous NT in response to stress requires the presence of NTS2 to stimulate corticotropin-releasing factor (CRF)-induced elevation of plasma corticosterone, and that NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.
NTS2 Positive_regulation (stimulate) of corticotropin-releasing factor in spinal cord associated with stress, pain and spinal cord
2) Confidence 0.35 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 0.92 Pain Relevance 0.96

General Comments

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