INT1653

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Context Info
Confidence 0.49
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.30
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DSP) structural molecule activity (DSP) plasma membrane (DSP)
protein binding, bridging (DSP) cytoplasm (DSP)
Anatomy Link Frequency
keratinocytes 1
T cells 1
DSP (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 14 99.50 Very High Very High Very High
Pain 4 99.28 Very High Very High Very High
dexamethasone 6 99.22 Very High Very High Very High
narcan 11 98.00 Very High Very High Very High
opiate 9 88.04 High High
Opioid 1 86.00 High High
midbrain 2 75.60 Quite High
anesthesia 4 9.60 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 57 99.76 Very High Very High Very High
Stress 14 99.68 Very High Very High Very High
Pain 3 99.28 Very High Very High Very High
Premature Birth 33 97.40 Very High Very High Very High
Sprains And Strains 12 96.00 Very High Very High Very High
Adhesions 51 91.44 High High
Immunotherapy Of Cancer 1 89.44 High High
Rupture 8 87.04 High High
Bullous Skin Disease 304 85.40 High High
Cancer 44 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was concluded from experiments in keratinocytes which showed that Rac 1 inactivation by transfection with a dominant-inactive mutant as well as inactivation of Rho A by C3 toxin for 25 min was sufficient to displace E-cadherin but not desmoplakin from cell junctions (Braga et al. 1997).
Neg (not) Positive_regulation (displace) of desmoplakin in keratinocytes
1) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.55 Pain Relevance 0
This resulted in three proteins which were significantly upregulated (desmoplakin isoform 1, stratifin and thrombospondin), but the possible role of these proteins in the pathogenesis of preterm birth is not yet known [53].


Positive_regulation (upregulated) of desmoplakin associated with premature birth
2) Confidence 0.06 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.66 Pain Relevance 0
The in vivo administration of ACTH, dexamethasone and morphine treatment resulted in an increase of DP IV activity in the cell suspension.
Positive_regulation (increase) of DP IV associated with dexamethasone and morphine
3) Confidence 0.06 Published 1989 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2544437 Disease Relevance 0.28 Pain Relevance 0.63
Morphine and D-Met2-Pro5-enkephalinamide resulted in a dose dependent activation of DP IV in T cells, an effect which could be modified by naloxone pretreatment.
Positive_regulation (activation) of DP IV in T cells associated with narcan and morphine
4) Confidence 0.06 Published 1989 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2544437 Disease Relevance 0.28 Pain Relevance 0.65
In adrenalectomized rats ACTH treatment failed to modify the enzyme activity, however, pain or emotional stress resulted in an elevated DP IV activity.
Positive_regulation (elevated) of DP IV associated with stress and pain
5) Confidence 0.06 Published 1989 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2544437 Disease Relevance 0.29 Pain Relevance 0.65
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Positive_regulation (increased) of DSP associated with breast cancer
6) Confidence 0.05 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.87 Pain Relevance 0
It was also found that chronic morphine treatment significantly increased the incorporation of 32Pi into synaptic TPI and DPI.
Positive_regulation (increased) of DPI associated with morphine
7) Confidence 0.04 Published 1979 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 223211 Disease Relevance 0 Pain Relevance 1.00
When injected into wild-type mice, this new aggregated and pathogenic PrP isoform induced neurological signs after about 130 DPI, with the terminal phase occurring around 150 DPI [22].
Positive_regulation (induced) of DPI
8) Confidence 0.03 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.38 Pain Relevance 0

General Comments

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