INT16531

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 1984
Last Reported 2008
Negated 4
Speculated 4
Reported most in Abstract
Documents 31
Total Number 35
Disease Relevance 2.12
Pain Relevance 14.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh1) extracellular region (Ghrh, Gh1) cytosol (Gh1)
signal transduction (Gh1) mitochondrion (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 13
neurons 4
median eminence 4
plasma 3
anterior 2
Ghrh (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 101 100.00 Very High Very High Very High
agonist 60 100.00 Very High Very High Very High
Morphine 22 99.88 Very High Very High Very High
opiate 12 99.84 Very High Very High Very High
dexamethasone 10 99.76 Very High Very High Very High
antagonist 89 99.74 Very High Very High Very High
substance P 32 99.50 Very High Very High Very High
Calcitonin gene-related peptide 56 99.38 Very High Very High Very High
Somatostatin 66 99.16 Very High Very High Very High
Intracerebroventricular 12 98.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 24 98.36 Very High Very High Very High
Hyperglycemia 2 98.30 Very High Very High Very High
Immunization 3 92.08 High High
Aging 9 78.52 Quite High
Body Weight 7 74.92 Quite High
Decapitation 1 74.44 Quite High
Eating Disorder 8 73.92 Quite High
Cancer 44 61.20 Quite High
Infection 2 60.60 Quite High
Stress 99 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that (a) pituitary responsiveness to GHRH changes throughout the estrous cycle is maximal in diestrus and minimal in proestrus; (b) GHRH stimulated GH secretion in intact and ovariectomized females on days 45, 60 and 90, but not on day 30; (c) the age increase of GH responsiveness to GHRH administration was slightly reduced in animals ovariectomized on day 23; (e) the age increase of pituitary GH content was similar in control and ovariectomized females; and (d) ovariectomy on day 83 reduced pituitary responsiveness to GHRH more effectively than ovariectomy on day 23.
GHRH Positive_regulation (stimulated) of Localization (secretion) of GH in pituitary
1) Confidence 0.64 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1834957 Disease Relevance 0 Pain Relevance 0.07
To characterize the mechanism(s) involved in vivo in the inhibition of GH by AMY, we examined, at first, the effects of AMY on GHRH-induced GH release in rats depleted of somatostatin by pretreatment (4 h before) with cysteamine (300 mg/kg s.c.).
GHRH Positive_regulation (induced) of Localization (release) of GH associated with somatostatin
2) Confidence 0.64 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 8538870 Disease Relevance 0 Pain Relevance 0.34
I.c.v. administration of AMY dose-dependently inhibited GH secretion induced by GHRH but when given peripherally, AMY did not modify the GH response to GHRH.
GHRH Positive_regulation (induced) of Localization (secretion) of GH
3) Confidence 0.64 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 8538870 Disease Relevance 0 Pain Relevance 0.11
Since GRF stimulates GH release through the activation of adenylate cyclase, intracellular cAMP levels were measured in the cultured pituitary cells.
GRF Positive_regulation (stimulates) of Localization (release) of GH in pituitary
4) Confidence 0.61 Published 1986 Journal Endocrinology Section Abstract Doc Link 3009151 Disease Relevance 0.40 Pain Relevance 0.10
In particular, activation of alpha 2-adrenoceptors stimulates GH secretion via endogenous GHRH release, although a mechanism operating to inhibit hypothalamic SS release cannot be excluded; stimulation of alpha 1-adrenoceptors is inhibitory to GH secretion exclusively via an increased release of hypothalamic SS.
GHRH Positive_regulation (stimulates) of Localization (secretion) of GH associated with somatostatin
5) Confidence 0.54 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.42
When CGRP was administered intracarotidly, even the dose of 10 micrograms/rat did not reduce the GH release induced by GHRH or morphine.
GHRH Neg (not) Positive_regulation (induced) of Localization (release) of GH associated with morphine and calcitonin gene-related peptide
6) Confidence 0.52 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2785661 Disease Relevance 0 Pain Relevance 1.00
These results indicate that 1) functional activation of alpha-2 adrenergic receptors by CLO increases GHRH release from the hypothalamus, 2) CLO, via GHRH, increases GH secretion and biosynthesis, which in turn feeds back in the hypothalamus to reduce GHRH biosynthesis, and 3) reduction of hypothalamic GH-stimulatory activity tones down the initial pituitary somatotropic hyperfunction.
GHRH Positive_regulation (increases) of Localization (secretion) of GH in hypothalamus associated with clonidine
7) Confidence 0.51 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.87
These results suggest that hyperglycemia does not change the GH response to GHRF and that elevation of plasma FFA suppresses GHRF-induced GH secretion by the stimulation of somatostatin secretion in rats.
GHRF-induced Positive_regulation (induced) of Localization (secretion) of GH in plasma associated with hyperglycemia and somatostatin
8) Confidence 0.50 Published 1986 Journal Endocrinology Section Abstract Doc Link 2870916 Disease Relevance 0.31 Pain Relevance 0.12
The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats.
GHRH Positive_regulation (induced) of Localization (release) of GH associated with intracerebroventricular
9) Confidence 0.46 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 8538870 Disease Relevance 0 Pain Relevance 0.07
The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats.
GH-releasing hormone Positive_regulation (induced) of Localization (release) of GH associated with intracerebroventricular
10) Confidence 0.46 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 8538870 Disease Relevance 0 Pain Relevance 0.05
Moreover, unlike GRF (10(-8) M), CLO (10(-6) to 10(-5) M) did not stimulate GH release in vitro from anterior pituitaries of 10-day-old rats.
GRF Neg (not) Positive_regulation (stimulate) of Localization (release) of GH in anterior associated with clonidine
11) Confidence 0.41 Published 1986 Journal Endocrinology Section Abstract Doc Link 3089765 Disease Relevance 0 Pain Relevance 0.92
A significant decrease of GRF-stimulated GH secretion of lean rat pituitary cells exposed to the obese serum was noted (P less than 0.05).
GRF Positive_regulation (stimulated) of Localization (secretion) of GH in pituitary associated with obesity
12) Confidence 0.41 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 2139233 Disease Relevance 0.86 Pain Relevance 0.04
In 1-day-old rats, neither CLO (15 micrograms/100 g BW, sc) nor GRF (20 ng/100 g BW, sc) stimulated GH release, whereas significant GH stimulation was elicited by GRF, but not CLO, in 5-day-old rats and by both secretagogues in 10-day-old rats.
GRF Neg (nor) Positive_regulation (stimulated) of Localization (release) of GH associated with clonidine
13) Confidence 0.38 Published 1986 Journal Endocrinology Section Abstract Doc Link 3089765 Disease Relevance 0 Pain Relevance 0.96
Our first aim was to ascertain whether CLO elicits GH release in rat pups via GRF, and if this is the case, to evaluate the ontogenetic development in 1- to 10-day-old pups of the GH response to acute CLO or GRF administration and, finally, the effects of short term CLO or GRF treatment on plasma and pituitary GH concentrations and on the GH response to an acute challenge with the homologous secretagogue.
GRF Spec (whether) Positive_regulation (elicits) of Localization (release) of GH in pituitary associated with clonidine
14) Confidence 0.38 Published 1986 Journal Endocrinology Section Abstract Doc Link 3089765 Disease Relevance 0 Pain Relevance 0.68
To investigate the possible involvement of somatostatin (SRIF) in the inhibition of GH secretion by CGRP, the effect of the peptide on GHRH-induced GH release was also examined in rats with hypothalamic SRIF depletion obtained by pretreatment (4 h before) with cysteamine (300 mg/kg subcutaneously).
GHRH Positive_regulation (induced) of Localization (release) of GH associated with somatostatin and calcitonin gene-related peptide
15) Confidence 0.38 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2785661 Disease Relevance 0 Pain Relevance 0.92
Growth-hormone releasing factor (GRF) induces feeding and growth hormone (GH) release.
GRF Positive_regulation (induces) of Localization (release) of GH
16) Confidence 0.37 Published 1997 Journal Peptides Section Abstract Doc Link 9149291 Disease Relevance 0 Pain Relevance 0.47
Growth-hormone releasing factor (GRF) induces feeding and growth hormone (GH) release.
Growth-hormone releasing factor Positive_regulation (induces) of Localization (release) of GH
17) Confidence 0.37 Published 1997 Journal Peptides Section Abstract Doc Link 9149291 Disease Relevance 0 Pain Relevance 0.47
In this study, we utilized the immunocytochemical detection of Fos protein to examine the effects of morphine- and GH-releasing hormone (GHRH)-induced GH release on the activation of arcuate nucleus neurons following GHS administration.
GHRH Spec (examine) Positive_regulation (induced) of Localization (release) of GH in neurons associated with morphine
18) Confidence 0.36 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10461024 Disease Relevance 0 Pain Relevance 0.32
In this study, we utilized the immunocytochemical detection of Fos protein to examine the effects of morphine- and GH-releasing hormone (GHRH)-induced GH release on the activation of arcuate nucleus neurons following GHS administration.
GH-releasing hormone Spec (examine) Positive_regulation (induced) of Localization (release) of GH in neurons associated with morphine
19) Confidence 0.36 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10461024 Disease Relevance 0 Pain Relevance 0.32
Thus extracellular Na+ plays an important role in hGRF-induced GH secretion, especially in the process after cAMP production.
hGRF Positive_regulation (induced) of Localization (secretion) of GH
20) Confidence 0.35 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2833113 Disease Relevance 0 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox