INT165323

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 88.76 High High
Disease 1 77.68 Quite High
Reprotox - General 1 2 68.84 Quite High
Osteogenic Sarcomas 20 66.12 Quite High
Bone Cancer 1 62.00 Quite High
Malignant Neoplastic Disease 2 61.52 Quite High
Breast Cancer 1 57.40 Quite High
Carcinoma 1 50.00 Quite Low
Cancer 10 43.28 Quite Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the innovative approaches to addressing MDR is to inhibit MDR1 mRNA expression by RNA interference (RNAi).
Negative_regulation (inhibit) of Transcription (expression) of MDR1
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.56 Pain Relevance 0
The QRT - PCR analysis has shown that, when used simultaneously, DOX 1 microM and SUL 50 microM results in decreased mRNA level for MDR-1 and MRP-1.
Negative_regulation (decreased) of Transcription (level) of MDR-1
2) Confidence 0.28 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20037485 Disease Relevance 0.07 Pain Relevance 0

General Comments

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