INT165332

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.27
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
DLN 2
lung 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 60 100.00 Very High Very High Very High
dexamethasone 10 98.96 Very High Very High Very High
Arthritis 28 93.68 High High
Inflammation 60 92.96 High High
lidocaine 2 92.20 High High
agonist 8 85.52 High High
antagonist 7 82.96 Quite High
adenocard 18 67.44 Quite High
anesthesia 2 46.28 Quite Low
epidural 1 45.84 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 99.08 Very High Very High Very High
Cancer 42 98.64 Very High Very High Very High
Stress 3 98.22 Very High Very High Very High
Necrosis 3 98.16 Very High Very High Very High
Injury 6 97.08 Very High Very High Very High
Apoptosis 51 94.00 High High
Arthritis 29 93.68 High High
INFLAMMATION 78 92.96 High High
Death 6 92.56 High High
Neuroblastoma 2 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, pharmacological inhibition of Akt abolished the protective effect of dexamethasone against bupivacaine-induced cell injury.
Negative_regulation (abolished) of Negative_regulation (inhibition) of Akt associated with injury and dexamethasone
1) Confidence 0.42 Published 2010 Journal Neuroscience Section Abstract Doc Link 20038443 Disease Relevance 0.70 Pain Relevance 0.56
Analysis of synovia and DLN protein extracts revealed a decreased expression level of PI3K, PKB/Akt, IKK, NF-?
Negative_regulation (revealed) of Negative_regulation (level) of PKB/Akt in DLN
2) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526584 Disease Relevance 1.02 Pain Relevance 0.49
This initial increase may be the tumor cells protective response to a stress and it is postulated that attenuating pAKT levels may lead to a synergistic response if inhibitors of the Akt kinase phosphorylation process is introduced in conjunction with MGd.
Negative_regulation (introduced) of Negative_regulation (inhibitors) of Akt kinase associated with stress and cancer
3) Confidence 0.28 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673824 Disease Relevance 0.84 Pain Relevance 0
Importantly, reduced levels of phospho-Akt at Ser473 caused by morphine and H37Ra were inhibited in the lung from TLR9 KO mice (Fig. 3B).
Negative_regulation (inhibited) of Negative_regulation (reduced) of Akt in lung associated with targeted disruption and morphine
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.72 Pain Relevance 0.66
With TCR engagement there is a concomitant exclusion of the phosphatase CD45 from the lipid raft to prevent inactivation of kinases in the signaling platform [57].
Negative_regulation (prevent) of Negative_regulation (inactivation) of kinases
5) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0

General Comments

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