INT165337

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.16
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dkk1) extracellular region (Dkk1) plasma membrane (Dkk1)
Anatomy Link Frequency
plasma 1
synovial fluid 1
Dkk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 140 96.56 Very High Very High Very High
spinal inflammation 4 91.20 High High
antagonist 7 74.16 Quite High
Kinase C 1 51.92 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 140 96.56 Very High Very High Very High
Arthropathy 12 95.56 Very High Very High Very High
Osteophyte 12 93.36 High High
Disease 34 83.00 Quite High
Low Back Pain 4 75.00 Quite High
Fracture Healing 36 61.68 Quite High
Knee Osteoarthritis 6 50.00 Quite Low
Osteoporosis 36 30.96 Quite Low
Targeted Disruption 4 24.32 Low Low
Obesity 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies will be required to determine whether the concentrations of Dkk-1 in synovial fluid and plasma are related to the expression of Dkk-1 in joint tissues.
Spec (whether) Regulation (related) of Dkk-1 in plasma
1) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.01 Pain Relevance 0.30
SOX9 was also down-regulated after treatment of Ad-DKK1, suggesting an inhibition of chondrogenic differentiation after blocking of WNT/?
Regulation (regulated) of DKK1
2) Confidence 0.36 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.06 Pain Relevance 0.06
OBJECTIVE: Dkk-1 is an inhibitory molecule that regulates the Wnt pathway, which controls osteoblastogenesis.
Regulation (regulates) of Dkk-1
3) Confidence 0.30 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20039407 Disease Relevance 0.07 Pain Relevance 0.17
Additional studies will be required to determine whether the concentrations of Dkk-1 in synovial fluid and plasma are related to the expression of Dkk-1 in joint tissues.
Spec (whether) Regulation (related) of Dkk-1 in synovial fluid
4) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.01 Pain Relevance 0.30

General Comments

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