INT165338

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.64
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dkk1) extracellular region (Dkk1) plasma membrane (Dkk1)
Anatomy Link Frequency
plasma 1
synovial fluid 1
femur 1
Dkk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 142 98.56 Very High Very High Very High
cytokine 2 90.92 High High
rheumatoid arthritis 4 71.96 Quite High
Pain 6 66.24 Quite High
Arthritis 4 61.00 Quite High
antagonist 10 50.00 Quite Low
spinal inflammation 4 50.00 Quite Low
agonist 2 16.40 Low Low
Serotonin 14 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 142 98.56 Very High Very High Very High
Disease 47 97.44 Very High Very High Very High
Syndrome 6 92.40 High High
Retina Disease 2 89.80 High High
Low Back Pain 4 86.80 High High
Arthropathy 12 86.24 High High
Osteoporosis 22 81.04 Quite High
Rheumatoid Arthritis 4 71.96 Quite High
Pain 6 66.24 Quite High
Knee Osteoarthritis 6 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have hypothesized that Dkk-1 in plasma and synovial fluid might be associated with the severity of clinical outcomes in knee OA patients.
Dkk-1 Spec (might) Binding (associated) of in synovial fluid associated with osteoarthritis
1) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.19 Pain Relevance 0.49
The LRP5-G171V protein can no longer be bound by several proteins (such as Dkk1, Sost, and MESD) that may normally regulate its activity.
Dkk1 Neg (no) Binding (bound) of
2) Confidence 0.33 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.56 Pain Relevance 0
In addition, it has recently been shown that LRP4, which is expressed in bone and cultured osteoblasts, binds Dkk1 and sclerostin in vitro and that Lrp4-deficient mice revealed shortened total femur length, reduced cortical femoral perimeter, reduced total femur bone mineral content (BMC), and bone mineral density (BMD) [58].
Dkk1 Binding (binds) of in femur
3) Confidence 0.33 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.53 Pain Relevance 0.07
A functional ELISA was used to assess the binding of Dkk-1 to its receptor (low-density lipoprotein receptor-related protein 6).
Dkk-1 Binding (binding) of
4) Confidence 0.27 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20039407 Disease Relevance 0.18 Pain Relevance 0
We have hypothesized that Dkk-1 in plasma and synovial fluid might be associated with the severity of clinical outcomes in knee OA patients.
Dkk-1 Spec (might) Binding (associated) of in plasma associated with osteoarthritis
5) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.19 Pain Relevance 0.49

General Comments

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