INT165342

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 5.81
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TGFBI) extracellular space (TGFBI) extracellular region (TGFBI)
plasma membrane (TGFBI) extracellular matrix organization (TGFBI)
Anatomy Link Frequency
corneal epithelium 4
neuronal 2
astrocyte 2
nucleus 1
cornea 1
TGFBI (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 19 90.64 High High
Pain 20 80.56 Quite High
headache 3 50.00 Quite Low
nociceptor 3 10.00 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 5 98.96 Very High Very High Very High
Adenocarcinoma 2 98.64 Very High Very High Very High
Adhesions 21 97.68 Very High Very High Very High
Ganglion Cysts 46 96.80 Very High Very High Very High
Glaucoma 187 96.60 Very High Very High Very High
Amyloidosis 18 95.92 Very High Very High Very High
Disease 74 92.40 High High
Trichiasis 2 92.04 High High
Alzheimer's Dementia 50 91.56 High High
Corneal Disease 12 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the same year, it was also discovered that the protein product of the TGFBI gene is expressed in the cornea [5].
Gene_expression (expressed) of TGFBI in cornea
1) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2373796 Disease Relevance 0.13 Pain Relevance 0
Such typical clinical features of some patients illustrated the diagnosis of LCD I in these three families.
Gene_expression (diagnosis) of LCD I
2) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2443752 Disease Relevance 0 Pain Relevance 0
TGFBIp (the protein product of the TGFBI gene, also referred to as keratoepithelin, BIGH3, beta-igh3, ?
Gene_expression (product) of TGFBI
3) Confidence 0.59 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790481 Disease Relevance 1.73 Pain Relevance 0.12
The temporal expression of TGFBI during embryogenesis and wound healing suggests its important roles in the development and maintenance of ocular surface integrity [14-16].
Gene_expression (expression) of TGFBI associated with wound healing
4) Confidence 0.59 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790481 Disease Relevance 1.37 Pain Relevance 0.11
Interestingly, R124 in exon 4 of TGFBI is conserved among several species, including Homo sapiens, Mus musculus (R124), Pan troglodytes (R124), Macaca mulatta (R124), and Rattus norvegicus (R124), and is incompletely conserved in Gallus gallus (R117) and Danio rerio (R118).
Gene_expression (troglodytes) of TGFBI
5) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847680 Disease Relevance 0 Pain Relevance 0
As shown in Figure 7B, expression of neither native DREAM nor the EF-LCDmut affected significantly the activity of GAL-VDR or GAL-RAR in the absence of ligand.
Gene_expression (expression) of LCD
6) Confidence 0.58 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
LCD1 is slowly progressive and usually substantial discomfort and visual impairment occurs before the sixth decade.
Gene_expression (progressive) of LCD1
7) Confidence 0.58 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.09 Pain Relevance 0
TGFBI (BIGH3) was found to be expressed in the corneal epithelium [9].
Gene_expression (expressed) of BIGH3 in corneal epithelium
8) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2786890 Disease Relevance 0.23 Pain Relevance 0
TGFBI (BIGH3) was found to be expressed in the corneal epithelium [9].
Gene_expression (expressed) of TGFBI in corneal epithelium
9) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2786890 Disease Relevance 0.23 Pain Relevance 0
Initially known as kerato-epithelin, TGFBI is an extracellular matrix protein induced by transforming growth factor-beta 1 and is highly expressed in the corneal epithelium.
Gene_expression (expressed) of TGFBI in corneal epithelium
10) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847680 Disease Relevance 0.32 Pain Relevance 0.08
qRT-PCR was used to examine the expression of GPNMB, RBP1, CAPG, APOE, TGFBI, and TIMP1, which were identified in the nonhuman primate model, in immuno-enriched optic nerve head astrocytes from glaucomatous Caucasian American donors [see Additional file 7 and Additional file 8].
Spec (examine) Gene_expression (expression) of TGFBI in astrocytes
11) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.55 Pain Relevance 0
Differential expression of motility genes, including capping protein G (CAPG) and transforming growth factor beta-induced (TGFBI), was consistent with the reactive, migratory astrocyte phenotype characteristic of glaucoma [12], as were ECM remodeling genes, such as GPNMB [79,80] and TIMP1 [81,82].
Gene_expression (expression) of TGFBI in astrocyte associated with glaucoma
12) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.41 Pain Relevance 0
Initially known as kerato-epithelin, TGFBI is an extracellular matrix protein induced by transforming growth factor-beta 1 and is highly expressed in the corneal epithelium.
Gene_expression (expressed) of kerato-epithelin in corneal epithelium
13) Confidence 0.23 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847680 Disease Relevance 0.32 Pain Relevance 0.08
RESULTS: Chronic paracetamol exposure led to an increase in CSD frequency and CSD-evoked Fos expression in cerebral cortex indicating the increase in neuronal excitability.
Gene_expression (expression) of CSD in neuronal
14) Confidence 0.03 Published 2010 Journal Headache Section Body Doc Link 20039957 Disease Relevance 0.12 Pain Relevance 0
Prolonged medication exposure also facilitated trigeminal nociception as evident by an increase in CSD-evoked Fos expression in trigeminal nucleus caudalis.
Gene_expression (expression) of CSD in nucleus
15) Confidence 0.03 Published 2010 Journal Headache Section Body Doc Link 20039957 Disease Relevance 0.11 Pain Relevance 0
RESULTS: Chronic paracetamol exposure led to an increase in CSD frequency and CSD-evoked Fos expression in cerebral cortex indicating the increase in neuronal excitability.
Gene_expression (expression) of CSD in neuronal
16) Confidence 0.03 Published 2010 Journal Headache Section Body Doc Link 20039957 Disease Relevance 0.12 Pain Relevance 0

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