INT165361

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.80
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APAF1) Golgi apparatus (APAF1) nucleolus (APAF1)
nucleus (APAF1) intracellular (APAF1) cytoplasm (APAF1)
Anatomy Link Frequency
OGE 2
acinar cells 1
APAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 78.28 Quite High
chemokine 2 54.40 Quite High
Chronic pancreatitis 1 51.32 Quite High
ischemia 6 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 77 100.00 Very High Very High Very High
Apoptosis 143 97.72 Very High Very High Very High
Melanoma 54 95.72 Very High Very High Very High
Skin Cancer 280 84.80 Quite High
Injury 15 84.12 Quite High
Disease 19 78.64 Quite High
INFLAMMATION 8 78.28 Quite High
Cancer 83 76.32 Quite High
Parkinson's Disease 1 75.00 Quite High
Stress 30 71.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The change of Psim by 50% was observed in the presence of CXCL10 in treated acinar cells along with enhanced expression of Cytochrome C, apaf-1 and caspase 9/3 activation.
Positive_regulation (activation) of apaf-1 in acinar cells
1) Confidence 0.39 Published 2010 Journal Int J Exp Pathol Section Abstract Doc Link 20041963 Disease Relevance 1.10 Pain Relevance 0.08
Using the DNMT inhibitor, they were able to restore APAF-1 levels, apoptosome function and chemosensitivity.
Positive_regulation (restore) of APAF-1
2) Confidence 0.39 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 1.22 Pain Relevance 0
-actin, H2O2 treatment alone showed a slight decrease in the level of Bcl-2 to 0.95 fold of control but a large increase in the level of tBid, Apaf-1 and cytosolic CytC, the coactivators of apoptosome for the activation of caspase-9, to 4.81, 1.06, and 1.75 fold of control, respectively.
Positive_regulation (increase) of Apaf-1
3) Confidence 0.20 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.22 Pain Relevance 0
Apoptosis occurs via two interconnected pathways: the extrinsic (death receptor) and intrinsic (mitochondrial-dependent) pathways, both of which ultimately lead to the activation of effector-caspases (caspases-3, -6, -7), the final mediators of cell death,[10] PTEN, CDKN2A and APAF-1.[4]
Positive_regulation (activation) of APAF-1 associated with apoptosis and death
4) Confidence 0.17 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 1.18 Pain Relevance 0
Further investigation showed that OGE pretreatment inhibited H2O2-induced activation of caspase-3 and caspase-9, as well as H2O2-induced upregulation of proapoptotic Apaf-1 and the release of cytosolic cytochrome c, but has little effect on the activation of caspase-8.
Positive_regulation (activation) of Apaf-1 in OGE
5) Confidence 0.13 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952314 Disease Relevance 0.55 Pain Relevance 0.04
Further investigation showed that OGE pretreatment inhibited H2O2-induced activation of caspase-3 and caspase-9, as well as H2O2-induced upregulation of proapoptotic Apaf-1 and the release of cytosolic cytochrome c, but has little effect on the activation of caspase-8.
Positive_regulation (upregulation) of Apaf-1 in OGE
6) Confidence 0.13 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952314 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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