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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.78
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CEACAM8) plasma membrane (CEACAM8)
Anatomy Link Frequency
neutrophils 4
CEACAM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 99.16 Very High Very High Very High
Inflammation 114 95.24 Very High Very High Very High
Inflammatory mediators 6 81.92 Quite High
rheumatoid arthritis 1 81.20 Quite High
metalloproteinase 6 80.40 Quite High
Inflammatory response 9 65.36 Quite High
cytokine 34 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 205 100.00 Very High Very High Very High
Adhesions 40 99.52 Very High Very High Very High
INFLAMMATION 140 95.24 Very High Very High Very High
Atherosclerosis 2 81.96 Quite High
Rheumatoid Arthritis 1 81.20 Quite High
Cardiovascular Disease 1 80.32 Quite High
Sepsis 7 79.32 Quite High
Coronary Heart Disease 2 75.00 Quite High
Dengue 88 72.72 Quite High
Disease 40 54.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum concentrations of MMPs and their inhibitors, CD11b and CD66b expression on neutrophils were sequentially measured before induction of anesthesia, at the initiation of CPB, after 30 minutes of CPB, at the end of CPB, 4 and 48 hours after CPB.
Positive_regulation (measured) of Gene_expression (expression) of CD66b in neutrophils associated with anesthesia
1) Confidence 0.49 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.28 Pain Relevance 0.39
A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.
Positive_regulation (supported) of Gene_expression (expression) of CEACAM-8 in neutrophils associated with dengue hemorrhagic fever and adhesions
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.33 Pain Relevance 0.26
Following resuscitation, both patient groups exhibited significant PMN degranulation, as evidenced by significantly higher surface expression of the specific granule marker CD66b in comparison to control.
Positive_regulation (higher) of Gene_expression (expression) of CD66b
3) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.17 Pain Relevance 0

General Comments

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