INT165379

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.21
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CEACAM8) plasma membrane (CEACAM8)
Anatomy Link Frequency
neutrophils 4
monocytes 1
immune cells 1
CEACAM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 97.48 Very High Very High Very High
Inflammation 190 95.32 Very High Very High Very High
metalloproteinase 18 90.16 High High
Inflammatory mediators 10 84.04 Quite High
cytokine 100 83.64 Quite High
rheumatoid arthritis 2 80.32 Quite High
fibrosis 1 79.00 Quite High
Inflammatory response 21 75.12 Quite High
cva 15 46.00 Quite Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 205 100.00 Very High Very High Very High
Adhesions 120 99.52 Very High Very High Very High
INFLAMMATION 251 95.32 Very High Very High Very High
Severe Acute Respiratory Syndrome 48 94.52 High High
Brain Injury 216 92.84 High High
Necrosis 6 84.28 Quite High
Cancer 7 83.92 Quite High
Lymphopenia 2 83.08 Quite High
Atherosclerosis 2 81.08 Quite High
Rheumatoid Arthritis 3 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum concentrations of MMPs and their inhibitors, CD11b and CD66b expression on neutrophils were sequentially measured before induction of anesthesia, at the initiation of CPB, after 30 minutes of CPB, at the end of CPB, 4 and 48 hours after CPB.
Gene_expression (expression) of CD66b in neutrophils associated with anesthesia
1) Confidence 0.75 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.28 Pain Relevance 0.39
CD11b and CD66b expression on neutrophils increased at the initiation of CPB.
Gene_expression (expression) of CD66b in neutrophils
2) Confidence 0.75 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.22 Pain Relevance 0.27
Additionally we measured CD11b and CD66b molecule expression on neutrophils.
Gene_expression (expression) of CD66b in neutrophils
3) Confidence 0.75 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.31 Pain Relevance 0.40
A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.
Gene_expression (expression) of CEACAM-8 in neutrophils associated with dengue hemorrhagic fever and adhesions
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.32 Pain Relevance 0.26
Following resuscitation, both patient groups exhibited significant PMN degranulation, as evidenced by significantly higher surface expression of the specific granule marker CD66b in comparison to control.
Gene_expression (expression) of CD66b
5) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.12 Pain Relevance 0
Figure 2(A-B) illustrates the temporal pattern of cell surface CD66b and CD63 degranulation marker expression on PMNs.
Gene_expression (expression) of CD66b
6) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.11 Pain Relevance 0
Relative to control, NS patients showed up to a 2-fold higher surface expression of CD62L, CD11b and CD66b on polymorphonuclear neutrophils (PMNs) and monocytes that persisted for 48-h.
Gene_expression (expression) of CD66b in monocytes
7) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2819256 Disease Relevance 0.99 Pain Relevance 0.19
CEACAM 8 is expressed by activated monocytes and granulocytes, and significant up-regulation of this gene indicates the involvement of innate immune cells in SARS.
Gene_expression (expressed) of CEACAM 8 in immune cells associated with severe acute respiratory syndrome
8) Confidence 0.15 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.87 Pain Relevance 0.13

General Comments

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