INT165400

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 4.25
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TST) small molecule metabolic process (TST) RNA binding (TST)
plasma membrane (TST) cellular nitrogen compound metabolic process (TST)
Anatomy Link Frequency
external 2
eyes 1
canal 1
arm 1
meshwork 1
TST (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 56 88.24 High High
withdrawal 52 72.32 Quite High
Opioid 3 67.84 Quite High
Versed 12 60.56 Quite High
Pain 16 50.00 Quite Low
Acupuncture 2 50.00 Quite Low
analgesia 2 50.00 Quite Low
Inflammation 8 40.76 Quite Low
antidepressant 12 40.00 Quite Low
sSRI 20 39.40 Quite Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 125 99.84 Very High Very High Very High
Open-angle Glaucoma 45 99.18 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 348 98.34 Very High Very High Very High
Disease 59 85.60 High High
Hepatic Insufficiency 12 84.48 Quite High
Renal Failure 8 80.80 Quite High
Sleep Disorders 28 78.20 Quite High
Endometriosis (extended) 16 64.96 Quite High
Pain 16 61.76 Quite High
Glaucoma 87 48.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MA also increased SPT and TST, but the changes were not significantly different from those induced by SA.
Positive_regulation (increased) of TST
1) Confidence 0.68 Published 2010 Journal Eur J Pain Section Body Doc Link 20045360 Disease Relevance 0.05 Pain Relevance 0
Compared to SA, EA significantly increased both SPT and TST immediately after the treatment on the treatment leg as well as 24h after on both the treatment and non-treatment legs (ANOVA, p<0.05).
Positive_regulation (increased) of TST in legs
2) Confidence 0.59 Published 2010 Journal Eur J Pain Section Body Doc Link 20045360 Disease Relevance 0.06 Pain Relevance 0
Group A includes 22 eyes of 18 patients with uncontrolled OAG, despite receiving maximum tolerable medical treatment, which underwent RDS with the removal of the inner wall of Schlemm’s canal and the external layers of the trabecular meshwork with external trabeculectomy.
Positive_regulation (underwent) of RDS in meshwork associated with open-angle glaucoma
3) Confidence 0.52 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2893765 Disease Relevance 0.51 Pain Relevance 0
Group B includes 20 eyes of 17 patients with uncontrolled OAG, despite receiving maximum tolerable medical treatment, that have undergone RDS without the removal of the external layers of trabecular meshwork and the inner wall of Schlemm’s canal (without external trabeculectomy).
Positive_regulation (undergone) of RDS in canal associated with open-angle glaucoma
4) Confidence 0.52 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2893765 Disease Relevance 0.51 Pain Relevance 0
The aim of our study is to compare the postoperative results of RDS with external trabeculectomy to RDS alone (without external trabeculectomy) in patients with medically uncontrolled OAG, in order to determine whether the external trabeculectomy improves the effectiveness of RDS in IOP regulation.


Spec (whether) Positive_regulation (effectiveness) of RDS in external associated with open-angle glaucoma and ocular hypertension
5) Confidence 0.38 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2893765 Disease Relevance 0.52 Pain Relevance 0
Group B included 20 eyes of 17 patients which had undergone RDS alone.
Positive_regulation (undergone) of RDS in eyes
6) Confidence 0.35 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2893765 Disease Relevance 0.47 Pain Relevance 0
Group A included 22 eyes of 18 patients with open angle glaucoma (OAG) under maximum medical treatment, which underwent RDS – a modified method of performing DS – with the removal of the inner wall of Schlemm’s canal (external trabeculectomy) and without using any implant.
Positive_regulation (underwent) of RDS in external associated with open-angle glaucoma
7) Confidence 0.35 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2893765 Disease Relevance 0.37 Pain Relevance 0
Johnston et al.31 also demonstrated that RDS can be effective in recruiting MSM.
Positive_regulation (effective) of RDS
8) Confidence 0.32 Published 2009 Journal J Urban Health Section Body Doc Link PMC2705484 Disease Relevance 0 Pain Relevance 0.06
Wang et al.28 demonstrated that RDS can be effective for recruiting non-injecting DU, specifically MDMA/ecstasy users and illicit stimulant users29 in non-metropolitan settings in central Ohio.
Positive_regulation (effective) of RDS
9) Confidence 0.32 Published 2009 Journal J Urban Health Section Body Doc Link PMC2705484 Disease Relevance 0 Pain Relevance 0.07
To better understand the sources and relative contributions of recruitment bias, we examined discrepancies between network compositions of those recruited and those who refused coupons; we explored the relationship between recruiters and recruits to determine whether recruits were known to recruiters, an important requirement of RDS; we assessed the samples for possible homophily bias; we conducted a sensitivity analysis to test the assumption of random recruitment; and we examined points at which samples reached equilibrium.
Spec (whether) Positive_regulation (requirement) of RDS
10) Confidence 0.32 Published 2009 Journal J Urban Health Section Body Doc Link PMC2705484 Disease Relevance 0 Pain Relevance 0
Accordingly, the decrease of SOL, number of awakenings, and number of nights with one awakening, and the increase of TST and sleep quality remained significantly different from baseline during the 6 months of open-label treatment (Table 2b).
Positive_regulation (increase) of TST
11) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655082 Disease Relevance 0.30 Pain Relevance 0.07
In studies comparing zopiclone 7.5 mg with placebo in patients with chronic insomnia the active drug was found to reduce both SOL and the number of awakenings, and to increase TST and sleep quality (Duriez et al 1979; Chaudoir et al 1983; Mamelak et al 1983; Beaumont and Holland 1990; Pecknold et al 1990).
Positive_regulation (increase) of TST associated with sleep initiation and maintenance disorders
12) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655082 Disease Relevance 0.51 Pain Relevance 0.09
Zopiclone significantly reduced the SOL and the number of nocturnal awakenings, and increased the TST compared with placebo.
Positive_regulation (increased) of TST
13) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655082 Disease Relevance 0.32 Pain Relevance 0.03
Conversely, in cases where differing clinical manifestations of HRD arise from the same gene mutation (for example, adult vitelliform, central areolar choroidal, and butterfly-shaped dystrophies all arise from a mutation in the RDS gene on the short arm of chromosome six (Table 1)), the same corrective gene therapy might be applied to patients spanning more than one dystrophy, eliciting wider clinical impact.
Positive_regulation (mutation) of RDS in arm
14) Confidence 0.18 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.24 Pain Relevance 0
In these studies the drug significantly reduced sleep onset latency (SOL), the number of awakenings, and wake time after sleep onset (WASO) whereas total sleep time (TST) and quality of sleep were increased in non-elderly and elderly subjects.
Positive_regulation (increased) of TST
15) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2655082 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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