INT165401

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
anakinra 9 99.68 Very High Very High Very High
rheumatoid arthritis 66 99.44 Very High Very High Very High
cytokine 28 95.76 Very High Very High Very High
antagonist 3 92.08 High High
Adalimumab 8 73.12 Quite High
Infliximab 18 72.52 Quite High
Etanercept 18 70.40 Quite High
Inflammation 17 68.96 Quite High
Arthritis 6 52.64 Quite High
spinal inflammation 2 45.60 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 67 99.44 Very High Very High Very High
Disease Progression 2 89.04 High High
Toxicity 10 86.32 High High
Lymphatic System Cancer 5 83.84 Quite High
Syndrome 3 71.36 Quite High
INFLAMMATION 20 68.96 Quite High
Disease 19 67.92 Quite High
Juvenile Chronic Polyarthritis 2 54.24 Quite High
Crystal Associated Disease 2 47.04 Quite Low
Low Back Pain 2 45.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anakinra is the recombinant form of IL-1Ra, and has proven to be well tolerated and indicated in the treatment of rheumatoid arthritis.
Phosphorylation (form) of IL-1Ra associated with anakinra and rheumatoid arthritis
1) Confidence 0.09 Published 2010 Journal Joint Bone Spine Section Abstract Doc Link 20045371 Disease Relevance 0.45 Pain Relevance 0.28
The fourth biological agent approved by the FDA for the treatment of RA is Anakinra, a recombinant form of IL-1RA whose molecular mechanism was explained above.
Phosphorylation (form) of IL-1RA associated with anakinra and rheumatoid arthritis
2) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 1.06 Pain Relevance 0.63

General Comments

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