INT165431

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.52 Pain Relevance 0.79

cytosol (BLMH) peptidase activity (BLMH) nucleus (BLMH) cytoplasm (BLMH)

BLMH (Homo sapiens)

Pain Link Frequency Relevance Heat Tetrahydrobiopterin 6 100.00 Pain 5 99.04 GCH1 2 93.60 Lasting pain 2 90.00

Disease Link Frequency Relevance Heat Pain 5 99.04 Neuropathic Pain 1 88.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reducing the elevated BH4 levels associated with pain to baseline, while maintaining sufficient BH4 levels to limit side effects is the goal of discovery programs for novel therapeutics targeting GCH1 or SPR.

Positive_regulation (elevated) of BH4 associated with pain, tetrahydrobiopterin and gch1

1) Confidence 0.15 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.52 Pain Relevance 0.79

General Comments

This test has worked.