INT165432

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Context Info
Confidence 0.13
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.62
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BLMH) peptidase activity (BLMH) nucleus (BLMH)
cytoplasm (BLMH)
BLMH (Homo sapiens)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 24 100.00 Very High Very High Very High
Pain 5 99.04 Very High Very High Very High
GCH1 2 94.12 High High
Lasting pain 2 90.52 High High
Inflammation 32 70.60 Quite High
cva 19 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 5 99.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.20 Very High Very High Very High
Neuropathic Pain 1 89.24 High High
Stress 38 80.08 Quite High
Metabolic Syndrome 39 78.32 Quite High
Prediabetic State 30 78.00 Quite High
Diabetes Mellitus 84 77.36 Quite High
INFLAMMATION 36 70.60 Quite High
Disease 18 68.64 Quite High
Injury 7 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reducing the elevated BH4 levels associated with pain to baseline, while maintaining sufficient BH4 levels to limit side effects is the goal of discovery programs for novel therapeutics targeting GCH1 or SPR.
Negative_regulation (Reducing) of BH4 associated with pain, tetrahydrobiopterin and gch1
1) Confidence 0.13 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.52 Pain Relevance 0.79
Folic acid is not only a methyl donor and aids in the control of elevated homocysteine but also an electron and hydrogen donor, which brings BH2 and BH3 back to the requisite completely reduced BH4.
Negative_regulation (reduced) of BH4 associated with tetrahydrobiopterin and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.01 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 0.88 Pain Relevance 0.29
If BH4 is deficient in supply or function the eNOS reaction not only is capable of uncoupling with subsequent excess [O2'] and [ONOO'] but also is at a disadvantage in that there would be less BH4 to scavenge these local occurring reactive oxygen species being produced in excess amounts [27].
Negative_regulation (deficient) of BH4 associated with tetrahydrobiopterin
3) Confidence 0.01 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 0.22 Pain Relevance 0.29

General Comments

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