INT165433

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.06
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BLMH) peptidase activity (BLMH) nucleus (BLMH)
cytoplasm (BLMH)
BLMH (Homo sapiens)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 12 100.00 Very High Very High Very High
Pain 10 99.80 Very High Very High Very High
Lasting pain 4 98.80 Very High Very High Very High
GCH1 4 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 10 99.80 Very High Very High Very High
Neuropathic Pain 2 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rate-limiting enzyme in BH4 synthesis, guanosine triphosphate cyclohydrolase 1 (GCH1), and sepiapterin reductase (SPR) are both promising drug targets based on initial active-site characterization of the SARs of these two enzymes.
Gene_expression (synthesis) of BH4 associated with tetrahydrobiopterin and gch1
1) Confidence 0.20 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.53 Pain Relevance 0.78
The recently discovered link between tetrahydrobiopterin (BH4) synthesis and pain in preclinical models and humans provides a promising new approach for treating neuropathic and other forms of chronic pain.
Gene_expression (synthesis) of BH4 associated with pain, tetrahydrobiopterin, lasting pain and neuropathic pain
2) Confidence 0.17 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.53 Pain Relevance 0.75

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox