INT165434

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.14
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPR) small molecule metabolic process (SPR) oxidoreductase activity (SPR)
nucleolus (SPR) nucleus (SPR) cytoplasm (SPR)
SPR (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 6 100.00 Very High Very High Very High
Tetrahydrobiopterin 18 98.72 Very High Very High Very High
Pain 15 97.34 Very High Very High Very High
Lasting pain 6 96.12 Very High Very High Very High
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 15 97.34 Very High Very High Very High
Neuropathic Pain 3 94.84 High High
Lyme Disease 2 93.52 High High
Disease 79 76.64 Quite High
Classical Swine Fever 1 75.92 Quite High
Pancreatic Cancer 1 67.92 Quite High
Adhesions 1 63.92 Quite High
Cancer 2 57.36 Quite High
Pulmonary Disease 93 8.24 Low Low
Nicotine Addiction 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rate-limiting enzyme in BH4 synthesis, guanosine triphosphate cyclohydrolase 1 (GCH1), and sepiapterin reductase (SPR) are both promising drug targets based on initial active-site characterization of the SARs of these two enzymes.
Regulation (targets) of sepiapterin reductase associated with tetrahydrobiopterin and gch1
1) Confidence 0.24 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.53 Pain Relevance 0.79
The rate-limiting enzyme in BH4 synthesis, guanosine triphosphate cyclohydrolase 1 (GCH1), and sepiapterin reductase (SPR) are both promising drug targets based on initial active-site characterization of the SARs of these two enzymes.
Regulation (targets) of SPR associated with tetrahydrobiopterin and gch1
2) Confidence 0.24 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.53 Pain Relevance 0.79
Reducing the elevated BH4 levels associated with pain to baseline, while maintaining sufficient BH4 levels to limit side effects is the goal of discovery programs for novel therapeutics targeting GCH1 or SPR.
Regulation (targeting) of SPR associated with pain, tetrahydrobiopterin and gch1
3) Confidence 0.24 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.49 Pain Relevance 0.75
Several of the studies mentioned in Table 2 have used SPR to detect biomarkers at clinically relevant concentrations highlighting the feasibility of using SPR in a clinical setting.
Regulation (using) of SPR
4) Confidence 0.07 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.59 Pain Relevance 0

General Comments

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