INT165435

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BLMH) peptidase activity (BLMH) nucleus (BLMH)
cytoplasm (BLMH)
BLMH (Homo sapiens)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 6 100.00 Very High Very High Very High
Pain 5 99.04 Very High Very High Very High
GCH1 2 94.12 High High
Lasting pain 2 90.52 High High
Disease Link Frequency Relevance Heat
Pain 5 99.04 Very High Very High Very High
Neuropathic Pain 1 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reducing the elevated BH4 levels associated with pain to baseline, while maintaining sufficient BH4 levels to limit side effects is the goal of discovery programs for novel therapeutics targeting GCH1 or SPR.
Negative_regulation (Reducing) of Positive_regulation (elevated) of BH4 associated with pain, tetrahydrobiopterin and gch1
1) Confidence 0.13 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.52 Pain Relevance 0.79

General Comments

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