INT165446

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.88
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 11 99.78 Very High Very High Very High
fluoxetine 7 99.58 Very High Very High Very High
COX2 2 95.24 Very High Very High Very High
COX-2 inhibitor 2 83.40 Quite High
cINOD 2 81.56 Quite High
antidepressant 1 73.48 Quite High
rheumatoid arthritis 5 73.08 Quite High
cytokine 1 64.60 Quite High
Pain 2 61.84 Quite High
Inflammation 1 55.44 Quite High
Disease Link Frequency Relevance Heat
Death 3 99.96 Very High Very High Very High
Apoptosis 7 96.76 Very High Very High Very High
Ovarian Cancer 3 88.16 High High
Squamous Cell Carcinoma 3 85.68 High High
Cancer 3 79.16 Quite High
Rheumatoid Arthritis 5 73.08 Quite High
Pain 2 61.84 Quite High
Arthritis 2 61.64 Quite High
INFLAMMATION 1 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HA also decreased the degree of phosphorylation and nuclear translocation of NF-kappaB enhanced by LPS.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of NF-kappaB
1) Confidence 0.56 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.49 Pain Relevance 0.38
Oxidant scavengers and Bay 11-7085 [an inhibitor of nuclear factor kappaB (NF-kappaB) activation] prevented the FLX-induced cell death, increase in phosphorylated inhibitory kappaB-alpha and NF-kappaB p65 levels, and binding of NF-kappaB p65 to DNA.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of kappaB associated with death and fluoxetine
2) Confidence 0.45 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20050848 Disease Relevance 0.74 Pain Relevance 0.62
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Positive_regulation (caused) of Phosphorylation (dephosphorylation) of NF-kappaB associated with aspirin
3) Confidence 0.33 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.65 Pain Relevance 0.66

General Comments

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