INT165449

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.47
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ceacam3) cellular_component (Ceacam3) biological_process (Ceacam3)
Anatomy Link Frequency
CeA 4
output neurons 2
Ceacam3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 268 100.00 Very High Very High Very High
Central grey 89 100.00 Very High Very High Very High
narcan 2 98.92 Very High Very High Very High
opioid receptor 6 98.16 Very High Very High Very High
antagonist 9 97.52 Very High Very High Very High
anesthesia 12 96.44 Very High Very High Very High
Pain 14 94.84 High High
withdrawal 13 94.68 High High
antinociception 3 94.28 High High
Visceral pain 9 87.96 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 97 100.00 Very High Very High Very High
Shock 109 99.56 Very High Very High Very High
Stress 127 98.88 Very High Very High Very High
Nociception 4 96.16 Very High Very High Very High
Anxiety Disorder 115 94.88 High High
Pain 15 94.84 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

9 87.96 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

24 83.52 Quite High
Unconsciousness 4 56.76 Quite High
Post-traumatic Stress Disorder 17 26.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
stimulation inhibits CeA output neurons (Quirk et al. [53]), and that excitotoxic lesions of the mPFC or its pharmacologic inactivation with muscimol potently inhibit fear, specifically reducing active stress coping such as shock-probe burying (Shah and Treit [54];
Negative_regulation (inhibits) of Gene_expression (output neurons) of CeA in output neurons associated with stress, shock, anxiety disorder and amygdala
1) Confidence 0.36 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.65 Pain Relevance 0.27
Intra-CeA PACAP infusion reduces number of shocks without
Negative_regulation (reduces) of Gene_expression (infusion) of CeA associated with shock and amygdala
2) Confidence 0.36 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.28
Interestingly, the amtinociceptive effect induced by intra-CeA injection of galanin was blocked by intra-CeA injection of naloxone, a common opioid receptor antagonist, indicating an involvement of opioid receptors in the galanin-induced antinociception in the CeA of rats.
Negative_regulation (blocked) of Gene_expression (injection) of CeA in CeA associated with antinociception, antagonist, narcan, opioid receptor and amygdala
3) Confidence 0.35 Published 2010 Journal Brain Res. Section Abstract Doc Link 20051236 Disease Relevance 0.08 Pain Relevance 1.44
We speculate that the decreased CRF expression in the CeA of anesthetized rats is related to the reduction of cortical activity caused by general anesthesia, which disrupts the relay of pain-related information from the neocortex to the amygdala.
Negative_regulation (decreased) of Gene_expression (expression) of CeA in amygdala associated with pain, anesthesia and amygdala
4) Confidence 0.33 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.38 Pain Relevance 1.17
left hemisphere CeA-PAG evoked
Negative_regulation (hemisphere) of Gene_expression (evoked) of CeA associated with central grey and amygdala
5) Confidence 0.14 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.42 Pain Relevance 0.29

General Comments

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