INT165452

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Context Info
Confidence 0.63
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 23.63
Pain Relevance 9.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vtcn1) cellular_component (Vtcn1)
Anatomy Link Frequency
T cells 6
macrophages 3
nerves 1
vesicles 1
Vtcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 1393 100.00 Very High Very High Very High
agonist 129 100.00 Very High Very High Very High
Eae 18 100.00 Very High Very High Very High
rheumatoid arthritis 1200 99.92 Very High Very High Very High
Inflammation 429 99.68 Very High Very High Very High
chemokine 40 99.00 Very High Very High Very High
cytokine 104 97.20 Very High Very High Very High
Neuropathic pain 12 94.92 High High
Sciatic nerve 6 93.12 High High
Inflammatory response 72 92.08 High High
Disease Link Frequency Relevance Heat
Arthritis 1345 100.00 Very High Very High Very High
Injury 18 100.00 Very High Very High Very High
Targeted Disruption 89 99.98 Very High Very High Very High
Rheumatoid Arthritis 1232 99.92 Very High Very High Very High
Ovarian Cancer 17 99.84 Very High Very High Very High
INFLAMMATION 502 99.68 Very High Very High Very High
Autoimmune Disease 315 99.60 Very High Very High Very High
Disease 547 99.40 Very High Very High Very High
Disease Progression 113 98.64 Very High Very High Very High
Cancer 181 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B7-H1 mRNA was markedly induced in WT nerves after CCI, and macrophages could be identified as major B7-H1 source.
Gene_expression (source) of B7-H1 in macrophages associated with eae
1) Confidence 0.63 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20051242 Disease Relevance 1.33 Pain Relevance 0.92
Overall, TNFalpha and MCP-1 levels in B7-H1-deficient nerves dramatically exceeded those in WT controls.
Gene_expression (levels) of B7-H1 in nerves
2) Confidence 0.54 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20051242 Disease Relevance 1.37 Pain Relevance 1.07
B7-H1 mRNA was markedly induced in WT nerves after CCI, and macrophages could be identified as major B7-H1 source.
Gene_expression (source) of B7-H1 in macrophages associated with eae
3) Confidence 0.54 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20051242 Disease Relevance 1.36 Pain Relevance 0.95
This is shown in vivo by transgenic expression of sH4 or B7-H4 genetic knockout.
Gene_expression (expression) of B7-H4 associated with targeted disruption
4) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.35 Pain Relevance 0.46
Therefore, a potential approach to suppressing autoimmune diseases is to increase the expression of B7-H4 in the form of agonist in order to engage its putative receptor.
Gene_expression (expression) of B7-H4 associated with autoimmune disease and agonist
5) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.56 Pain Relevance 0.36
In addition, expression of agonist B7-H4Ig fusion protein significantly inhibits T cell and autoantibody-mediated responses.
Gene_expression (expression) of B7-H4Ig in T cell associated with agonist
6) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.28 Pain Relevance 0.45
Both overexpression of sH4 and deletion of B7-H4 caused inflammation in the mice; symptoms appeared earlier and were more severe.
Gene_expression (overexpression) of B7-H4 associated with inflammation
7) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2760136 Disease Relevance 1.08 Pain Relevance 0.50
B7-H4Ig and the control vector were transfected into 293 T cells and the same level of production of Fc was confirmed with two plasmids (unpublished data).
Gene_expression (transfected) of B7-H4Ig in T cells
8) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.65 Pain Relevance 0.37
Production of decoy B7-H4 in these patients may facilitate disease progression by enhancing innate immune responses, leading to amplified adaptive autoimmune responses against self antigens.
Gene_expression (Production) of B7-H4 associated with disease progression
9) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.27 Pain Relevance 0.44
Increased CIA clinical score induced by sH4 was eliminated by this treatment (B7-H4VC+Ctl IgG group versus B7-H4VC+anti-Gr-1 mAb group) (Figure 4B).
Gene_expression (group) of B7-H4VC associated with arthritis
10) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.10 Pain Relevance 0.42
Using a hydrodynamic injection method to express B7-H4 plasmid in vivo, we demonstrated that expression of sH4 promotes autoimmune responses, leading to progression of CIA, and similar results are also observed in B7-H4–deficient mice.
Gene_expression (express) of B7-H4 associated with arthritis
11) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.43 Pain Relevance 0.45
In contrast, introduction of the plasmid encoding B7-H4Ig could prevent disease induction of CIA.
Gene_expression (introduction) of B7-H4Ig associated with disease and arthritis
12) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.65 Pain Relevance 0.55
Cell surface B7-H4 is normally not detectable in normal tissues, but its surface expression could be up-regulated on macrophages and tumor cells by inflammatory cytokines including IL-10 and IL-6 [25].
Gene_expression (expression) of B7-H4 in macrophages associated with inflammation, cancer and cytokine
13) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.12 Pain Relevance 0.25
To do so, we constructed an expression vector, B7-H4VC, in which the truncated gene encoding both IgV and IgC domains was placed under the control of the cytomegalovirus (CMV) immediate early promoter.
Gene_expression (expression) of B7-H4VC associated with cytomegalovirus infection
14) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.90 Pain Relevance 0.17
Soluble B7-H4 (sH4) was also detected in ovarian cancer patients as a potential biomarker, but the mechanism of production and the function of sH4 are unknown [28].
Gene_expression (detected) of B7-H4 associated with ovarian cancer
15) Confidence 0.10 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.02 Pain Relevance 0.22
Expression in vivo of an agonist, a B7-H4-immunoglobulin Fc fusion protein, profoundly suppressed disease progression in the mouse model.


Gene_expression (on) of B7-H4 associated with agonist and disease progression
16) Confidence 0.10 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2760136 Disease Relevance 1.24 Pain Relevance 0.47
Increased CIA clinical score induced by sH4 was eliminated by this treatment (B7-H4VC+Ctl IgG group versus B7-H4VC+anti-Gr-1 mAb group) (Figure 4B).
Gene_expression (group) of B7-H4VC associated with arthritis
17) Confidence 0.09 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.05 Pain Relevance 0.42
Suppression of CIA by Agonist B7-H4
Gene_expression (Suppression) of B7-H4 associated with agonist and arthritis
18) Confidence 0.09 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.78 Pain Relevance 0.46
Using a hydrodynamic injection method to express B7-H4 plasmid in vivo, we demonstrated that expression of sH4 promotes autoimmune responses, leading to progression of CIA, and similar results are also observed in B7-H4–deficient mice.
Gene_expression (deficient) of B7-H4 associated with arthritis
19) Confidence 0.08 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.60 Pain Relevance 0.53
-induced CD40 expression in the immature murine DC cell line, BC1 (Iijima et al., 2003), and blocked the expression of high levels of surface molecules such as MHCs, B7-1, and B7-2 after lipopolysaccharide treatment in human DC (Nouri-Shirazi & Guinet, 2002).
Gene_expression (expression) of B7-1
20) Confidence 0.02 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0

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