INT165453

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.91
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vtcn1) cellular_component (Vtcn1)
Anatomy Link Frequency
macrophages 1
Vtcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 87 99.66 Very High Very High Very High
Eae 6 99.20 Very High Very High Very High
rheumatoid arthritis 75 96.36 Very High Very High Very High
Neuropathic pain 4 94.92 High High
Sciatic nerve 2 93.12 High High
cytokine 8 90.68 High High
Inflammation 28 86.48 High High
Peripheral nervous system 1 79.96 Quite High
Inflammatory response 6 72.64 Quite High
Peripheral nerve injury 2 70.76 Quite High
Disease Link Frequency Relevance Heat
Arthritis 84 99.66 Very High Very High Very High
Injury 6 99.20 Very High Very High Very High
Autoimmune Disease 18 96.68 Very High Very High Very High
Rheumatoid Arthritis 77 96.36 Very High Very High Very High
Neuropathic Pain 4 94.92 High High
Disease 33 93.68 High High
Cancer 4 90.88 High High
Necrosis 2 90.40 High High
INFLAMMATION 34 86.48 High High
Nervous System Injury 2 70.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B7-H1 mRNA was markedly induced in WT nerves after CCI, and macrophages could be identified as major B7-H1 source.
Positive_regulation (induced) of B7-H1 in macrophages associated with eae
1) Confidence 0.56 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20051242 Disease Relevance 1.23 Pain Relevance 0.89
While our results in the mouse CIA model suggest a role of B7-H4 in pathogenesis of CIA, one should be cautious because the CIA model does not mimic human RA in all aspects, and it remains to be tested whether sH4 participates in the development of human RA.
Positive_regulation (role) of B7-H4 associated with rheumatoid arthritis and arthritis
2) Confidence 0.08 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.69 Pain Relevance 0.58

General Comments

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