INT165457

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.46
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC1A3) transmembrane transport (SLC1A3)
Anatomy Link Frequency
neuronal 1
SLC1A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 84 100.00 Very High Very High Very High
diclofenac 4 99.96 Very High Very High Very High
cINOD 2 99.36 Very High Very High Very High
cytokine 20 80.32 Quite High
Glutamate receptor 29 74.60 Quite High
Spinal cord 2 71.68 Quite High
Dorsal horn 1 70.92 Quite High
Kinase C 6 64.96 Quite High
Hippocampus 2 60.88 Quite High
Central nervous system 2 48.08 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.50 Very High Very High Very High
INFLAMMATION 4 99.24 Very High Very High Very High
Diabetes Mellitus 87 97.96 Very High Very High Very High
Diabetic Retinopathy 9 97.12 Very High Very High Very High
Retina Disease 1 79.80 Quite High
Glaucoma 1 78.80 Quite High
Retinal Diseases 1 78.08 Quite High
Cognitive Disorder 8 63.36 Quite High
Ganglion Cysts 5 39.44 Quite Low
Obesity 1 35.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two non-steroidal anti-inflammatory drugs, niflumic acid and diclofenac, inhibit the human glutamate transporter EAAT1 through different mechanisms.
Negative_regulation (inhibit) of EAAT1 associated with glutamate, inflammation, cinod and diclofenac
1) Confidence 0.42 Published 2010 Journal J. Pharmacol. Sci. Section Title Doc Link 20051656 Disease Relevance 0.20 Pain Relevance 0.47
Moreover, the high-affinity L-glutamate/L-aspartate transporter (GLAST) is impaired in retinal Müller cells isolated from STZ-induced diabetic rats, probably due to oxidation of the glutamate transporter [27].
Negative_regulation (impaired) of GLAST associated with glutamate and diabetes mellitus
2) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.16 Pain Relevance 0.47
Even more convincing for the role of astroglia in keeping the [Glu]ec low, it has been demonstrated with knockout techniques in rats that loss of GLT-1 or GLAST produces elevated [Glu]ec and neurodegeneration characteristic of excitotoxicity, while the loss of neuronal glutamate transporter does not elevate [Glu]ec [15].


Negative_regulation (loss) of GLAST in neuronal associated with targeted disruption and glutamate
3) Confidence 0.12 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.10 Pain Relevance 0.62

General Comments

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