INT165460

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.19
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC1A3) transmembrane transport (SLC1A3)
Anatomy Link Frequency
plasma 2
astrocytes 1
oocytes 1
cerebellum 1
microglia 1
SLC1A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 711 100.00 Very High Very High Very High
cINOD 2 98.68 Very High Very High Very High
adenocard 8 97.28 Very High Very High Very High
cytokine 84 97.20 Very High Very High Very High
diclofenac 4 95.84 Very High Very High Very High
Kinase C 24 95.44 Very High Very High Very High
nMDA receptor 52 92.80 High High
agonist 12 81.64 Quite High
antagonist 15 80.36 Quite High
Locus ceruleus 8 79.92 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 522 99.76 Very High Very High Very High
INFLAMMATION 61 98.56 Very High Very High Very High
Diabetes Mellitus 87 97.96 Very High Very High Very High
Autism 314 97.60 Very High Very High Very High
Diabetic Retinopathy 9 97.12 Very High Very High Very High
Disease 46 96.96 Very High Very High Very High
Aging 1 96.96 Very High Very High Very High
Stress 48 95.36 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 27 94.40 High High
Cognitive Disorder 76 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro insulin impairs glial glutamate uptake by reducing expression of GLAST/EAAT1 transporter [54] and by possibly impairing ATP-dependent pump processes resulting in transmitter exocytosis [55].
Gene_expression (expression) of EAAT1 associated with glutamate
1) Confidence 0.75 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0 Pain Relevance 0.51
We investigated the effects of non-steroidal anti-inflammatory drugs on substrate-induced currents of L-glutamate (L-Glu) transporter EAAT1 expressed in Xenopus laevis oocytes.
Gene_expression (expressed) of EAAT1 in oocytes associated with glutamate, inflammation and cinod
2) Confidence 0.66 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20051656 Disease Relevance 0.17 Pain Relevance 0.42
Moreover, the high-affinity L-glutamate/L-aspartate transporter (GLAST) is impaired in retinal Müller cells isolated from STZ-induced diabetic rats, probably due to oxidation of the glutamate transporter [27].
Neg (impaired) Gene_expression (impaired) of GLAST associated with glutamate and diabetes mellitus
3) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.16 Pain Relevance 0.47
Recently, Wang and coworkers [22] showed a reduced expression of GLT-1 and GLAST, and also, an impaired glutamate transport in human primary astrocytes, by TNF-?.
Gene_expression (expression) of GLAST in astrocytes associated with glutamate
4) Confidence 0.26 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.37 Pain Relevance 0.52
GLAST glutamate aspartate transporter
Gene_expression (transporter) of GLAST associated with glutamate
5) Confidence 0.22 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.77 Pain Relevance 0.66
To investigate the specificity of EAAT2 down-regulation, we evaluated the effect of NMO-IgG on the EAAT1 glutamate transporter, which is expressed constitutively in nonneural HEK-293 cells (Fig. 3 E).
Gene_expression (expressed) of EAAT1 associated with neuromyelitis optica and glutamate
6) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.71 Pain Relevance 0.08
NMO patient sera did not appreciably affect EAAT1 expression in these cells (Fig. 4 D), in contrast to EAAT2 loss from the plasma membrane.
Gene_expression (expression) of EAAT1 in plasma associated with neuromyelitis optica
7) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.69 Pain Relevance 0.08
Those cells express both EAAT1 and EAAT2, but are devoid of AQP4 (Fig. 3).
Gene_expression (express) of EAAT1
8) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.71 Pain Relevance 0.06
A large number of factors have been shown to affect the activity and expression of the glutamate transporters GLT-1 and GLAST.
Gene_expression (expression) of GLAST associated with glutamate
9) Confidence 0.20 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.09 Pain Relevance 0.66
In fact GLAST and GLT-1 have different expression patterns.
Gene_expression (expression) of GLAST
10) Confidence 0.19 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.12 Pain Relevance 0.62
EAAT2 and EAAT1 are enriched in separate microdomains of the astrocytic plasma membrane (18, 19); EAAT2 is enriched in regions that highly express AQP4 (18).
Gene_expression (enriched) of EAAT1 in plasma
11) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.50 Pain Relevance 0.08
Commercial antibodies (AQP4, EAAT1, EAAT2, or GFP; 2 ?
Gene_expression (antibodies) of EAAT1
12) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.09 Pain Relevance 0.13
However, uptake of glutamate was unaffected in the presence of Na+, suggesting that EAAT1 expressed constitutively in these cells is not functional.


Gene_expression (expressed) of EAAT1 associated with glutamate
13) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.25 Pain Relevance 0.28
Furthermore, both the mRNA and protein levels of EAAT 1 and EAAT 2 were found to be significantly increased in the autistic cerebellum (Purcell et al., 2001).
Gene_expression (levels) of EAAT 1 in cerebellum associated with autism
14) Confidence 0.06 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.38 Pain Relevance 0.40
Activated microglia express the glutamate transporter EAAT-1 and the density of this transporter increases with progression through the disease process.
Gene_expression (express) of EAAT-1 in microglia associated with glutamate and disease
15) Confidence 0.03 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.16 Pain Relevance 0.47

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