INT165469

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.71
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
intestinal cells 1
pancreas 1
fa (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 99.74 Very High Very High Very High
Neurotransmitter 2 98.24 Very High Very High Very High
Raphe 2 96.44 Very High Very High Very High
Pain 6 94.20 High High
cva 2 93.92 High High
Migraine 2 93.48 High High
Inflammation 52 80.60 Quite High
Bile 12 80.24 Quite High
Bioavailability 8 71.60 Quite High
Nicotine 8 47.36 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 28 98.04 Very High Very High Very High
Toxicity 24 97.60 Very High Very High Very High
Anxiety Disorder 2 95.24 Very High Very High Very High
Injury 16 94.40 High High
Pain 2 94.20 High High
Cv General 3 Under Development 2 93.92 High High
Headache 2 93.48 High High
Stress 68 90.96 High High
Chromosome Aberrations 4 87.08 High High
Hyperglycemia 4 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparative QSAR study was done on thirtytwo (phenylpiperazinyl-alkyl) oxindoles using stepwise regression, PCRA, FA-MLR and PLS techniques to find structurally significant models.
Gene_expression (regression) of FA-MLR
1) Confidence 0.14 Published 2010 Journal Eur J Med Chem Section Abstract Doc Link 20053486 Disease Relevance 0.37 Pain Relevance 0.36
Predictive comparative QSAR modelling of (phenylpiperazinyl-alkyl) oxindoles as selective 5-HT1A antagonists by stepwise regression, PCRA, FA-MLR and PLS techniques.
Gene_expression (regression) of FA-MLR associated with antagonist
2) Confidence 0.14 Published 2010 Journal Eur J Med Chem Section Title Doc Link 20053486 Disease Relevance 0.37 Pain Relevance 0.38
In these cells, FA is readily conjugated and the resulting metabolites leave the intestinal cells only towards the serosal side because no conjugated forms of FA are detected in the intestinal lumen.
Neg (no) Gene_expression (detected) of FA in intestinal cells
3) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127228 Disease Relevance 0.20 Pain Relevance 0.18
Metabolism and Absorption of FA
Gene_expression (Metabolism) of FA
4) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127228 Disease Relevance 0 Pain Relevance 0
Since FA prevents the formation of ROS, the syntheses of these enzymes are not affected [60].
Neg (prevents) Gene_expression (prevents) of FA
5) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127228 Disease Relevance 0.52 Pain Relevance 0
FA, which has been shown to have antioxidant properties, helps to neutralize the free radicals produced by streptozotocin in the pancreas and thereby decrease the toxicity of streptozotocin.
Gene_expression (produced) of FA in pancreas associated with toxicity
6) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127228 Disease Relevance 1.25 Pain Relevance 0.07

General Comments

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