INT165481

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.55
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
brain 3
liver 1
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 12 80.24 Quite High
local anesthetic 2 50.00 Quite Low
Hippocampus 10 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Limbic system 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 118 99.68 Very High Very High Very High
Stress 6 96.64 Very High Very High Very High
Death 29 95.56 Very High Very High Very High
Starvation 16 95.24 Very High Very High Very High
Disease 157 93.76 High High
Targeted Disruption 36 58.28 Quite High
Immunization 15 52.80 Quite High
Aging 5 52.16 Quite High
Infection 61 50.00 Quite Low
Lewy Body Disease 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the immunohistochemical analysis (Figure 2), by immunoblot, levels of LC3 and Cathepsin D in the membrane fractions were reduced in the DLB cases compared to non-demented controls (Figure S1A, C).
Negative_regulation (reduced) of Gene_expression (levels) of LC3 associated with parkinson's disease
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.07
In contrast to the results obtained in liver and brain [19], LC3 protein expression in CCDWT was very low, and cathepsin D deficiency was associated with increased expression of both light (LC3II, membrane-bound) and heavy (LC3I, cytosolic) forms of LC3.
Negative_regulation (low) of Gene_expression (expression) of LC3 in brain
2) Confidence 0.33 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
Consistent with the immunohistochemical analysis (Figure 2), by immunoblot, levels of LC3 and Cathepsin D in the membrane fractions were reduced in the DLB cases compared to non-demented controls (Figure S1A, C).
Negative_regulation (reduced) of Gene_expression (levels) of LC3 associated with parkinson's disease
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.07
LC3 staining was often high in cells with autofluorescent granules (Fig 5c, right panel), although since autofluorescence was visible in both red and green channels, it was not possible to definitively determine that LC3 was present in the autofluorescent granules themselves.
Negative_regulation (determine) of Gene_expression (present) of LC3
4) Confidence 0.32 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0.05 Pain Relevance 0
Increased lethality and a decrease in GFP-LC3 levels in Atg7 deficient flies indicated that autophagy deficiency was deleterious during stress-inducing conditions such as starvation, oxidative stress and metamorphosis.
Negative_regulation (decrease) of Gene_expression (levels) of GFP-LC3 associated with stress and starvation
5) Confidence 0.20 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.54 Pain Relevance 0
In contrast to the results obtained in liver and brain [19], LC3 protein expression in CCDWT was very low, and cathepsin D deficiency was associated with increased expression of both light (LC3II, membrane-bound) and heavy (LC3I, cytosolic) forms of LC3.
Negative_regulation (low) of in liver Gene_expression (expression) of LC3 in brain
6) Confidence 0.11 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
Consistent with the results of the GFP-LC3 puncta assay (Figure 3A and 3B), the conversion of LC3 from LC3-I to LC3-II was much reduced in WT and ?
Negative_regulation (reduced) of Gene_expression (conversion) of LC3
7) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.07 Pain Relevance 0
Novel aspects of the morphological analysis include reduced LC3 labelling of the large vacuoles in cells treated with 3-methyl-adenine, inhibition of CD63 labelling of these vacuoles by co-expression of dominant negative Rab7, retention of secretory green fluorescent protein (GFP) possessing a signal sequence in vacuolar cells, and partial vacuole labelling with lysosomal-associated membrane protein 1 (LAMP1).
Negative_regulation (reduced) of Gene_expression (expression) of LC3
8) Confidence 0.04 Published 2010 Journal Can J Anaesth Section Body Doc Link 20054683 Disease Relevance 0.07 Pain Relevance 0

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